23088618800ISSNE: 3006-094XP: 3105-0786مجلة علوم طبّی غالبMJhttps://mj.ghalib.edu.af/index.php/mj1250315580200دورۀ دوم، شمارة دوم، خزان و زمستان 1404، صص65-74-1905-24003000پوهنتون غالبپیشرفتهای بیولوژی مالیکولی در زمینه تشخیص و کنترل ویروس تب خونریزیدهنده کریمه-کنگو: پیامدها برای افغانستان194364810731500209677011756200303877910033000رحیم بخش فقیریار۱، احمد سعید یعقوبی۲۱. پوهنحی/دانشکده تعلیم و تربیه، پوهنتون/دانشگاه هرات، هرات، افغانستان۲. پوهنحی/ دانشکده طب معالجوی، پوهنتون/دانشگاه جامی، هرات، افغانستانچکیده اطلاعات مقالهزمینه و هدف: تب خونریزیدهنده کریمه-کنگو (CCHF) یک بیماری خطرناک ناشی از نیش کنه است که توسط ویروس CCHFV ایجاد شده و میزان مرگومیر آن ۱۰ تا ۴۰ فیصد میباشد. افغانستان به دلیل وجود کنههای هیالوما و ضعف در سیستم تشخیصی، با افزایش موارد این بیماری مواجه است. این مقاله پیشرفتهای بیولوژی مالیکولی در تحقیقات مربوط به CCHFV و کاربردهای بالقوه آن در افغانستان را با تمرکز بر روشهای تشخیصی، اپیدمیولوژی و توسعه واکسن بررسی میکند.روش بررسی: مرور سیستماتیک در پایگاههای داده PubMed، Scopus و Google Scholar (۲۰۰۷–۲۰۲۳) انجام شد. پس از حذف مطالعات تکراری و غربالگری، ۳۲ مطالعه مورد تحلیل قرار گرفتند که شامل بینشهای ژنومی، روشهای تشخیص مالیکولی و راهکارهای درمانی بودند.یافتهها: ژنوم سهبخشی ویروس (بخشهای S، M، L) تنوع ژنتیکی بالایی دارد که تشخیص و طراحی واکسن را پیچیده میکند. RT-PCR به عنوان روش استاندارد تشخیصی شناخته میشود، در حالی که بیوسنسورهای جدید گزینههای سریع و قابل استفاده در مناطق دورافتاده را ارائه میدهند. مطالعات اپیدمیولوژی مالیکولی نشاندهنده انتقال مرزی سویههای مختلف در افغانستان است، با نرخ مرگومیر ۴۳.۳٪ (۲۰۱۶–۲۰۱۸). علیرغم نامزدهای امیدوارکننده واکسن (مانند RNA replicons و VLPs)، هنوز واکسن مجوزدار وجود ندارد.نتیجهگیری: پیشرفتهای مالیکولی پتانسیل بهبود مدیریت CCHF در افغانستان را دارند، اما نیازمند ادغام در سیستمهای صحی هستند. توسعه زیرساختها، ابزارهای تشخیصی محلی و همکاریهای بینالمللی برای کاهش مرگومیر و کنترل شیوع بیماری ضروری است.نوع مقاله: مروریتاریخ دریافت: 05/02/1404تاریخ پذیرش: 10/05/1404تاریخ نشر: 31/06/1404شناختنامة نویسندة مسؤول:پوهنحی/ دانشکده طب معالجوی، پوهنتون/دانشگاه جامی، هرات، افغانستان 7399406891100s.yaqobi@jami.edu.af کُد اختصاصیِ مقاله/ DOI:https://doi.org/10.58342/ghalibMj.V.2.I.2.6 واژهگانِ کلیدی: CCHF، CCHFV، زیستشناسی مولکولی، افغانستان، RT-PCR، بیوسنسورها، اپیدمیولوژی، توسعه واکسنارجاع به این مقاله: فقیریار ر، یعقوبی ا س. پیشرفتهای بیولوژی مالیکولی در زمینه تشخیص و کنترل ویروس تب خونریزیدهنده کریمه-کنگو: پیامدها برای افغانستان. [اینترنت]. 22 سپتامبر ۲۰۲5. [تاریخ برداشت]؛ 2(2): 65- 74: https://doi.org/10.58342/ghalibMj.V.2.I.2.6 56082331905000این مقاله تحت مجوز بینالمللی HYPERLINK "https://creativecommons.org/licenses/by/4.0/"Creative Commons Attribution ۴ International License ثبت میباشد.1210567937600GHALIB UNIVERSITYGHALIB MEDICAL JOURNAL MJhttps://mj.ghalib.edu.af/index.php/mj12407901905000Vol.2, Issue. 2, Autumn and winter 2025. pp 65-7424257015176500ISSNE: 3006-094XP: 3105-0786Advances in Molecular Biology of Crimean-Congo Hemorrhagic Fever Virus: Implications for Diagnosis and Control in Afghanistan420996342545004391025279400029095702721800 Rahim Bakhsh Faqiryar1, Ahmad Saeed Yaqubi21. Faculty of Education, Herat University, Herat, Afghanistan2. Faculty of Medicine, Jami University, Herat, AfghanistanArticle Information AbstractType: ReviewReceived: 25/04/2025Accepted: 01/08/2025Published: 22/09/2025*Present address and corresponding author:Ahmad Saeed YaqubiFaculty of Medicine, Jami University, Herat, Afghanistan4445731500 s.yaqobi@jami.edu.afDOI: https://doi.org/10.58342/ghalibMj.V.2.I.2.6Background: Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne disease caused by CCHFV, with high fatality rates (10–40%). Afghanistan, an endemic region, faces rising cases due to ecological suitability for Hyalomma ticks and limited diagnostic capacity. This review assesses molecular biology advancements in CCHFV research and their potential applications in Afghanistan, focusing on diagnostics, epidemiology, and vaccine development.Methods: A systematic literature search (2007–2023) was conducted across PubMed, Scopus, and Google Scholar. After deduplication and screening, 32 studies were analyzed, covering genomic insights, molecular diagnostics, and therapeutic strategies.Results: CCHFV’s tripartite RNA genome (S, M, L segments) exhibits high genetic diversity, complicating diagnostics and vaccine design. RT-PCR remains the gold standard for detection, while emerging biosensors offer rapid, field-deployable alternatives. Molecular epidemiology reveals cross-border transmission of diverse strains in Afghanistan, with a case fatality rate of 43.3% (2016–2018). Despite promising preclinical vaccine candidates (e.g., RNA replicons, VLPs), no licensed vaccine exists.Conclusion: Molecular advances hold promise for improving CCHF management in Afghanistan but require integration into public health systems. Prioritizing infrastructure development, localized diagnostic tools, and international collaborations is critical to reducing mortality and controlling outbreaks.Key words: CCHF, CCHFV, molecular biology, Afghanistan, RT-PCR, biosensors, epidemiology, vaccine developmentTo cite this article: Faqiryar R, Yaqubi A S. Advances in Molecular Biology of Crimean-Congo Hemorrhagic Fever Virus: Implications for Diagnosis and Control in Afghanistan. Ghalib Medical Journal. [Internet]. September 22, 2025. [taking date]; 2(2): 65-74: https://doi.org/10.58342/ghalibMj.V.2.I.2.6This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 International License 13335444500IntroductionCrimean–Congo hemorrhagic fever (CCHF) is a severe tick-borne zoonosis caused by the Crimean–Congo hemorrhagic fever virus (CCHFV), a member of the Nairovirus genus in the Nairoviridae family ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"m7ZqOB5x","properties":{"formattedCitation":"\\super [1]\\nosupersub{}","plainCitation":"[1]","noteIndex":0},"citationItems":[{"id":4466,"uris":["http://zotero.org/users/8987489/items/4MK9XV45"],"itemData":{"id":4466,"type":"article-journal","container-title":"Travel Medicine and Infectious Disease","DOI":"10.1016/j.tmaid.2020.101871","ISSN":"14778939","journalAbbreviation":"Travel Medicine and Infectious Disease","language":"en","page":"101871","source":"DOI.org (Crossref)","title":"The emerging tick-borne Crimean-Congo haemorrhagic fever virus: A narrative review","title-short":"The emerging tick-borne Crimean-Congo haemorrhagic fever virus","volume":"37","author":[{"family":"Serretiello","given":"Enrica"},{"family":"Astorri","given":"Roberta"},{"family":"Chianese","given":"Annalisa"},{"family":"Stelitano","given":"Debora"},{"family":"Zannella","given":"Carla"},{"family":"Folliero","given":"Veronica"},{"family":"Santella","given":"Biagio"},{"family":"Galdiero","given":"Marilena"},{"family":"Franci","given":"Gianluigi"},{"family":"Galdiero","given":"Massimiliano"}],"issued":{"date-parts":[["2020",9]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [1]. With case fatality rates ranging from 10% to over 40%, CCHF represents a major public health challenge in endemic regions, including Africa, the Middle East, Eastern Europe, and large parts of Asia ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"AxYVwWbN","properties":{"formattedCitation":"\\super [2]\\nosupersub{}","plainCitation":"[2]","noteIndex":0},"citationItems":[{"id":4467,"uris":["http://zotero.org/users/8987489/items/S3I2XV96"],"itemData":{"id":4467,"type":"article-journal","container-title":"International Journal of Infectious Diseases","DOI":"10.1016/j.ijid.2017.02.018","ISSN":"12019712","journalAbbreviation":"International Journal of Infectious Diseases","language":"en","page":"82-89","source":"DOI.org (Crossref)","title":"Current status of Crimean-Congo haemorrhagic fever in the World Health Organization Eastern Mediterranean Region: issues, challenges, and future directions","title-short":"Current status of Crimean-Congo haemorrhagic fever in the World Health Organization Eastern Mediterranean Region","volume":"58","author":[{"family":"Al-Abri","given":"Seif S."},{"family":"Abaidani","given":"Idris Al"},{"family":"Fazlalipour","given":"Mehdi"},{"family":"Mostafavi","given":"Ehsan"},{"family":"Leblebicioglu","given":"Hakan"},{"family":"Pshenichnaya","given":"Natalia"},{"family":"Memish","given":"Ziad A."},{"family":"Hewson","given":"Roger"},{"family":"Petersen","given":"Eskild"},{"family":"Mala","given":"Peter"},{"family":"Nhu Nguyen","given":"Tran Minh"},{"family":"Rahman Malik","given":"Mamunur"},{"family":"Formenty","given":"Pierre"},{"family":"Jeffries","given":"Rosanna"}],"issued":{"date-parts":[["2017",5]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [2]. Afghanistan, a country with high ecological compatibility for Hyalomma ticks—the primary vector for CCHFV—has experienced a rising trend in cases over recent years ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"6y1TXWbJ","properties":{"formattedCitation":"\\super [3]\\nosupersub{}","plainCitation":"[3]","noteIndex":0},"citationItems":[{"id":4469,"uris":["http://zotero.org/users/8987489/items/LQRWK95S"],"itemData":{"id":4469,"type":"article-journal","container-title":"International Journal of Acarology","DOI":"10.1080/01647954.2021.1954085","ISSN":"0164-7954, 1945-3892","issue":"6","journalAbbreviation":"International Journal of Acarology","language":"en","page":"510-519","source":"DOI.org (Crossref)","title":"Distribution and biodiversity components of hard ticks as potential vectors of Crimean-Congo haemorrhagic fever virus (CCHFV) in borderline of Iran-Afghanistan","volume":"47","author":[{"family":"Jafari","given":"Amirsajad"},{"family":"Asadolahi","given":"Sahar"},{"family":"Rasekh","given":"Mehdi"},{"family":"Saadati","given":"Dariush"},{"family":"Faghihi","given":"Faezeh"},{"family":"Fazlalipour","given":"Mehdi"},{"family":"Telmadarraiy","given":"Zakkyeh"}],"issued":{"date-parts":[["2021",8,18]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [3].Despite longstanding recognition of the disease since its first description in the Crimea in 1944, modern molecular biology techniques have significantly expanded our understanding of CCHFV biology. Molecular approaches have elucidated many aspects of the viral genome, protein structure, and mechanisms of pathogenesis ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"iDRcIgls","properties":{"formattedCitation":"\\super [4]\\nosupersub{}","plainCitation":"[4]","noteIndex":0},"citationItems":[{"id":4470,"uris":["http://zotero.org/users/8987489/items/ATS8H6PI"],"itemData":{"id":4470,"type":"article-journal","container-title":"Future Virology","DOI":"10.2217/fvl.10.23","ISSN":"1746-0794, 1746-0808","issue":"4","journalAbbreviation":"Future Virol.","language":"en","page":"469-479","source":"DOI.org (Crossref)","title":"Molecular Biology and Pathogenesis of Crimean–Congo Hemorrhagic Fever Virus","volume":"5","author":[{"family":"Kraus","given":"Annette A"},{"family":"Mirazimi","given":"Ali"}],"issued":{"date-parts":[["2010",7]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [4]. The virus possesses a tripartite negative-sense RNA genome encoding large polyproteins that undergo complex post-translational modifications ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"YZy9KwPK","properties":{"formattedCitation":"\\super [5]\\nosupersub{}","plainCitation":"[5]","noteIndex":0},"citationItems":[{"id":4471,"uris":["http://zotero.org/users/8987489/items/69Q4FBVK","http://zotero.org/users/8987489/items/5BQ22A69"],"itemData":{"id":4471,"type":"article-journal","container-title":"Laboratory Medicine","DOI":"10.1309/LMN1P2FRZ7BKZSCO","ISSN":"0007-5027, 1943-7730","issue":"3","journalAbbreviation":"Lab Med","language":"en","page":"180-189","source":"DOI.org (Crossref)","title":"Crimean-Congo Hemorrhagic Fever","volume":"46","author":[{"family":"Shayan","given":"Sara"},{"family":"Bokaean","given":"Mohammad"},{"family":"Shahrivar","given":"Mona Ranjvar"},{"family":"Chinikar","given":"Sadegh"}],"issued":{"date-parts":[["2015",8,1]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [5].More recent studies have capitalized on advanced diagnostic techniques—including real-time quantitative RT-PCR, antigen capture ELISAs, and biosensor-based assays—to improve early detection of CCHFV ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"0lc3UyTQ","properties":{"formattedCitation":"\\super [6]\\nosupersub{}","plainCitation":"[6]","noteIndex":0},"citationItems":[{"id":4473,"uris":["http://zotero.org/users/8987489/items/447N9HAL"],"itemData":{"id":4473,"type":"chapter","container-title":"Crimean-Congo Hemorrhagic Fever","event-place":"Dordrecht","ISBN":"978-1-4020-6105-9","language":"en","note":"DOI: 10.1007/978-1-4020-6106-6_18","page":"233-243","publisher":"Springer Netherlands","publisher-place":"Dordrecht","source":"DOI.org (Crossref)","title":"Laboratory Diagnosis of Crimean-Congo Hemorrhagic Fever","URL":"http://link.springer.com/10.1007/978-1-4020-6106-6_18","editor":[{"family":"Ergonul","given":"Onder"},{"family":"Whitehouse","given":"Chris A."}],"author":[{"family":"Zeller","given":"Hervé"}],"accessed":{"date-parts":[["2025",3,24]]},"issued":{"date-parts":[["2007"]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [6]. Next-generation sequencing and molecular epidemiological analyses have revealed significant genetic heterogeneity, with isolates clustering into distinct phylogenetic clades that often correlate with geographic distribution ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"SM99oZuo","properties":{"formattedCitation":"\\super [7]\\nosupersub{}","plainCitation":"[7]","noteIndex":0},"citationItems":[{"id":4474,"uris":["http://zotero.org/users/8987489/items/HIF3AZB3"],"itemData":{"id":4474,"type":"article-journal","container-title":"Comptes Rendus. Biologies","DOI":"10.5802/crbiol.78","ISSN":"1768-3238","issue":"1","language":"en","page":"17-36","source":"DOI.org (Crossref)","title":"Crimean-Congo hemorrhagic fever: a growing threat to Europe","title-short":"Crimean-Congo hemorrhagic fever","volume":"345","author":[{"family":"Freitas","given":"Natalia"},{"family":"Legros","given":"Vincent"},{"family":"Cosset","given":"François-Loïc"}],"issued":{"date-parts":[["2022",5,11]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [7].In Afghanistan, limited laboratory capacity and high occupational exposure—especially among livestock handlers, abattoir workers, and healthcare professionals—have resulted in increased morbidity and mortality ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"XzDHBC6x","properties":{"formattedCitation":"\\super [8\\uc0\\u8211{}10]\\nosupersub{}","plainCitation":"[8–10]","noteIndex":0},"citationItems":[{"id":4475,"uris":["http://zotero.org/users/8987489/items/GKYEWRMT"],"itemData":{"id":4475,"type":"article-journal","page":"1-7","title":"Crimean-Congo hemorrhagic fever a threat to public health.","volume":"2","author":[{"literal":"Munibullah"},{"family":"Yousaf","given":"A."},{"family":"Shah","given":"M."},{"literal":"Habibullah"},{"family":"Sadia","given":"H."},{"family":"Sohoo","given":"Mujeeb ur Rehman"}],"issued":{"date-parts":[["2018"]]}}},{"id":5276,"uris":["http://zotero.org/users/8987489/items/IF2A8F57"],"itemData":{"id":5276,"type":"article-journal","container-title":"Afghanistan Journal of Infectious Diseases","DOI":"10.60141/AJID/V.2.I.1.8","ISSN":"2959-6491","issue":"1","language":"en","page":"63-74","source":"www.ajid.ghalib.edu.af","title":"Epidemiology and Outcomes of Crimean-Congo Hemorrhagic Fever in Afghanistan: A Review of 2010–2019","title-short":"Epidemiology and Outcomes of Crimean-Congo Hemorrhagic Fever in Afghanistan","volume":"2","author":[{"family":"Rahmani","given":"Kubra"},{"family":"Behrad","given":"Raihana"},{"family":"Rahimi","given":"Ali"},{"family":"Shayan","given":"Sharareh"},{"family":"Uğurlu","given":"Gökçe"},{"family":"Shayan","given":"Nasar Ahmad"}],"issued":{"date-parts":[["2024",1,10]]}}},{"id":5278,"uris":["http://zotero.org/users/8987489/items/MQ48ILYP"],"itemData":{"id":5278,"type":"article-journal","container-title":"Ghalib Medical Journal","DOI":"10.58342/ghalibMj.V.2.I.1.2","ISSN":"3006-094X","issue":"1","journalAbbreviation":"Ghalib Medical Journal","language":"en","page":"22-9","source":"www.mj.ghalib.edu.af","title":"Knowledge, attitude, and practices regarding Crimean Congo hemorrhagic fever among students at Jami university, Herat, Afghanistan","volume":"2","author":[{"family":"Rahimi","given":"Ali"},{"family":"Masudi","given":"Mohammad"},{"family":"Salehi","given":"Sayed Aref"},{"family":"Binesh","given":"Mohammad Hadi"},{"family":"Hosaini","given":"Sayed Farooq"},{"family":"Shayan","given":"Nasar Ahmad"}],"issued":{"date-parts":[["1404"]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [8–10]. The prevalence of Hyalomma ticks in the region and the frequent human-animal interactions increase the risk of zoonotic transmission ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"xBEgbIO1","properties":{"formattedCitation":"\\super [11]\\nosupersub{}","plainCitation":"[11]","noteIndex":0},"citationItems":[{"id":4476,"uris":["http://zotero.org/users/8987489/items/MXHZ426A"],"itemData":{"id":4476,"type":"article-journal","container-title":"Antiviral Research","DOI":"10.1016/j.antiviral.2004.08.001","ISSN":"01663542","issue":"3","journalAbbreviation":"Antiviral Research","language":"en","license":"https://www.elsevier.com/tdm/userlicense/1.0/","page":"145-160","source":"DOI.org (Crossref)","title":"Crimean?Congo hemorrhagic fever","title-short":"Crimean?","volume":"64","author":[{"family":"Whitehouse","given":"C"}],"issued":{"date-parts":[["2004",12]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [11]. A study in Herat Province reported a case fatality rate of 22.2%, highlighting the urgent need for improved diagnostic and therapeutic strategies ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"WzZy6jFw","properties":{"formattedCitation":"\\super [12]\\nosupersub{}","plainCitation":"[12]","noteIndex":0},"citationItems":[{"id":4477,"uris":["http://zotero.org/users/8987489/items/M34P2QY3"],"itemData":{"id":4477,"type":"article-journal","container-title":"Biotechnology & Biotechnological Equipment","DOI":"10.5504/BBEQ.2011.0135","ISSN":"1310-2818, 1314-3530","issue":"4","journalAbbreviation":"Biotechnology & Biotechnological Equipment","language":"en","page":"3079-3085","source":"DOI.org (Crossref)","title":"Current State of Crimean-Congo Hemorrhagic Fever in Bulgaria","volume":"26","author":[{"family":"Kalvatchev","given":"Nikolay"},{"family":"Christova","given":"Iva"}],"issued":{"date-parts":[["2012",1]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [12].Recent advancements in molecular biology have contributed to improved strategies for CCHFV diagnostics, treatment, and vaccine development ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"u24A0eZv","properties":{"formattedCitation":"\\super [13]\\nosupersub{}","plainCitation":"[13]","noteIndex":0},"citationItems":[{"id":4479,"uris":["http://zotero.org/users/8987489/items/FY9WFVBD"],"itemData":{"id":4479,"type":"article-journal","title":"Crimean-Congo hemorrhagic fever: a global perspective.","author":[{"family":"Ergonul","given":"O."},{"family":"Whitehouse","given":"Chris A."}],"issued":{"date-parts":[["2007"]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [13]. Modern molecular techniques have enhanced our understanding of CCHFV and how these advances can be applied in the Afghan context for better diagnostic, therapeutic, and preventive measures ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"fONoyiB9","properties":{"formattedCitation":"\\super [14]\\nosupersub{}","plainCitation":"[14]","noteIndex":0},"citationItems":[{"id":4480,"uris":["http://zotero.org/users/8987489/items/NIL7RH66"],"itemData":{"id":4480,"type":"article-journal","container-title":"Medecine tropicale : revue du Corps de sante colonial","page":"429-38","title":"Crimean-Congo hemorrhagic fever: basics for general practitioners.","volume":"70 5-6","author":[{"family":"Flusin","given":"O."},{"family":"Iseni","given":"F."},{"family":"Rodrigues","given":"R."},{"family":"Paranhos-Baccalà","given":"G."},{"family":"Crance","given":"J."},{"family":"Marianneau","given":"P."},{"family":"Bouloy","given":"M."},{"family":"Peyrefitte","given":"C."}],"issued":{"date-parts":[["2010"]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [14]. These developments are contextualized within the epidemiological landscape of Afghanistan, highlighting methodological breakthroughs that have advanced the understanding of viral genomics, protein processing, and host-pathogen interactions ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"EfWI6UMP","properties":{"formattedCitation":"\\super [15]\\nosupersub{}","plainCitation":"[15]","noteIndex":0},"citationItems":[{"id":4481,"uris":["http://zotero.org/users/8987489/items/S4EQ55SG"],"itemData":{"id":4481,"type":"article-journal","container-title":"International Journal of Advanced Biochemistry Research","DOI":"10.33545/26174693.2018.v2.i1a.7","ISSN":"26174693, 26174707","issue":"1","journalAbbreviation":"Int. J. Adv. Biochem. Res.","page":"01-05","source":"DOI.org (Crossref)","title":"Review of epidemiology, diagnosis, control, therapeutics and vaccine development for Crimean-Congo hemorrhagic fever","volume":"2","author":[{"family":"Siddiqui","given":"Faizan Q"},{"family":"Parveen","given":"Ghazala"},{"family":"Hussain","given":"Shahzad"}],"issued":{"date-parts":[["2018",1,1]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [15]. Additionally, critical gaps are identified, and future directions for integrating molecular techniques into public health strategies to control CCHF in Afghanistan are explored ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"FhX6E5WV","properties":{"formattedCitation":"\\super [16]\\nosupersub{}","plainCitation":"[16]","noteIndex":0},"citationItems":[{"id":4483,"uris":["http://zotero.org/users/8987489/items/NQEKCCKW"],"itemData":{"id":4483,"type":"article-journal","container-title":"Revue Scientifique et Technique de l'OIE","DOI":"10.20506/rst.34.2.2365","ISSN":"0253-1933","issue":"2","journalAbbreviation":"Rev. Sci. Tech. OIE","page":"390-401","source":"DOI.org (Crossref)","title":"Crimean-Congo haemorrhagic fever: -EN- -FR- Fièvre hémorragique de Crimée-Congo -ES- Fiebre hemorrágica de Crimea-Congo","title-short":"Crimean-Congo haemorrhagic fever","volume":"34","author":[{"family":"Peyrefitte","given":"C."},{"family":"Marianneau","given":"P."},{"family":"Tordo","given":"N."},{"family":"Bouloy","given":"M."}],"issued":{"date-parts":[["2015",8,1]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [16]. The aim of this review is to assess the impact of molecular biology advancements on CCHFV research and explore their potential applications in Afghanistan.MethodsA comprehensive literature search was conducted to identify studies addressing molecular biology advances in CCHF and their application in Afghanistan. The search strategy combined traditional database queries with a snowballing technique—commonly used in systematic reviews—to maximize the capture of relevant articles. Specifically, the following steps were undertaken:Database SearchAn initial search was performed in popular scientific databases including PubMed, Scopus, and Web of Science. The search terms combined keywords such as “Crimean–Congo hemorrhagic fever,” “CCHFV,” “molecular biology,” “diagnostics,” “vaccine,” “Afghanistan”. The search was limited to articles published between 2007 and 2023.PubMed: 1059 articles were retrievedScopus: 745 articles were retrievedGoogle Scholar: 362 articles were retrievedDeduplication and ScreeningAfter removing 90 duplicate records, the titles and abstracts of the remaining 160 articles were screened for relevance based on predefined inclusion criteria (i.e., studies addressing molecular aspects of CCHFV, diagnostic innovations, vaccine development, or epidemiological data pertinent to Afghanistan). This screening resulted in the exclusion of 110 articles due to irrelevance or insufficient detail, leaving 50 articles for full-text review.Snowballing TechniqueIn addition to the database search, the references of the initially included articles were examined (snowballing) to identify further relevant studies. This approach yielded an additional 10 articles, bringing the final total to 40 studies that met the inclusion criteria.Data Extraction and SynthesisKey information was extracted from each of the 32 studies—including study design, time period, methodological approaches (e.g., RT-PCR protocols, biosensor development, next-generation sequencing), and key findings. Data were then organized thematically into sections covering genomic/proteomic insights, molecular diagnostics, molecular epidemiology, and novel therapeutic/vaccine strategies.Table 1. Summary of Search Strategy and Study Selection ProcessDatabaseQueryArticles RetrievedPubMed("Crimean–Congo hemorrhagic fever" OR "CCHFV") AND ("molecular biology" OR "diagnostics" OR "vaccine") OR ("Afghanistan")1059 (10 pages, 100 articles)ScopusTITLE-ABS-KEY ("Crimean–Congo hemorrhagic fever" OR "CCHFV") AND TITLE-ABS-KEY ("molecular biology" OR "diagnostics" OR "vaccine") OR TITLE-ABS-KEY ("Afghanistan")745 (10 pages, 100 articles)Google ScholarCrimean–Congo hemorrhagic fever CCHFV molecular biology diagnostics vaccine Afghanistan362 (10 pages, 100 articles)Total Articles Retrieved300DeduplicationDuplicate records removed90ScreeningArticles excluded based on irrelevance or insufficient detail110Full-Text ReviewArticles selected for full review50Snowballing TechniqueAdditional articles identified from references10Final Included StudiesStudies that met inclusion criteria32Table 1 outlines the systematic approach used to identify and select studies related to Crimean–Congo hemorrhagic fever (CCHFV), focusing on molecular biology, diagnostics, vaccines, and the geographic context of Afghanistan. Three databases—PubMed, Scopus, and Google Scholar—were queried using tailored search strings combining keywords such as "Crimean–Congo hemorrhagic fever," "CCHFV," "molecular biology," "diagnostics," "vaccine," and "Afghanistan." Initial searches yielded 300 articles (100 from each database after limiting results to 10 pages per source).Deduplication removed 90 duplicate records, leaving 210 unique articles. During screening, 110 articles were excluded due to irrelevance or insufficient detail, narrowing the pool to 100 studies. Subsequent full-text review further refined the selection to 50 articles meeting preliminary eligibility criteria. The snowballing technique (examining references of selected studies) identified 10 additional relevant articles, resulting in 60 candidates. After rigorous evaluation against inclusion criteria, 32 studies were retained for final analysis.This process highlights a structured, multi-stage methodology to ensure comprehensive and relevant study inclusion while minimizing bias, ultimately supporting robust evidence synthesis on CCHFV research and its implications for Afghanistan.ResultsGenomic and Proteomic Insights into CCHFVThe molecular characterization of CCHFV has revealed a complex genomic organization. The virus possesses a tripartite, negative-sense RNA genome consisting of the small (S), medium (M), and large (L) segments ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"3jjghBHp","properties":{"formattedCitation":"\\super [17]\\nosupersub{}","plainCitation":"[17]","noteIndex":0},"citationItems":[{"id":4487,"uris":["http://zotero.org/users/8987489/items/XAM3AWA3"],"itemData":{"id":4487,"type":"article-journal","container-title":"Virus Research","DOI":"10.1016/j.virusres.2024.199464","ISSN":"01681702","journalAbbreviation":"Virus Research","language":"en","page":"199464","source":"DOI.org (Crossref)","title":"Development of targeted whole genome sequencing approaches for Crimean-Congo haemorrhagic fever virus (CCHFV)","volume":"350","author":[{"family":"D'Addiego","given":"Jake"},{"family":"Shah","given":"Sonal"},{"family":"Pektaş","given":"Ayşe Nur"},{"family":"Bağci","given":"Bi̇nnur Köksal"},{"family":"Öz","given":"Murtaza"},{"family":"Sebastianelli","given":"Sasha"},{"family":"Elaldı","given":"Nazif"},{"family":"Allen","given":"David J"},{"family":"Hewson","given":"Roger"}],"issued":{"date-parts":[["2024",12]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [17]. The S segment encodes the nucleoprotein (NP), a critical component of the viral ribonucleoprotein complex. The M segment encodes a large glycoprotein precursor (GPC) that is processed into two envelope glycoproteins (Gn and Gc) and additional accessory proteins ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"WHa3Tt6w","properties":{"formattedCitation":"\\super [18]\\nosupersub{}","plainCitation":"[18]","noteIndex":0},"citationItems":[{"id":4488,"uris":["http://zotero.org/users/8987489/items/27PDIT9V"],"itemData":{"id":4488,"type":"article-journal","abstract":"Fungal segmented negative-sense RNA viruses (SNSRVs) have been frequently found. Only the large segment encoding RNA-dependent RNA polymerase (RdRp) has been reported in most fungal SNSRVs, except for a few fungal SNSRVs reported to encode nucleocapsids, nonstructural proteins, or movement proteins.\n , \n ABSTRACT\n \n Although segmented negative-sense RNA viruses (SNSRVs) have been frequently discovered in various fungi, most SNSRVs reported only the large segments. In this study, we investigated the diversity of the mycoviruses in the phytopathogenic fungus\n Fusarium asiaticum\n using the metatranscriptomic technique. We identified 17 fungal single-stranded RNA (ssRNA) viruses including nine viruses within\n Mitoviridae\n , one each in\n Narnaviridae\n ,\n Botourmiaviridae\n ,\n Hypoviridae\n ,\n Fusariviridae\n , and Narliviridae, two in\n Mymonaviridae\n , and one trisegmented virus temporarily named Fusarium asiaticum mycobunyavirus 1 (FaMBV1). The FaMBV1 genome comprises three RNA segments, large (L), medium (M), and small (S) with 6,468, 2,639, and 1,420 nucleotides, respectively. These L, M, and S segments putatively encode the L protein, glycoprotein, and nucleocapsid, respectively. Phylogenetic analysis based on the L protein showed that FaMBV1 is phylogenetically clustered with Alternaria tenuissima negative-stranded RNA virus 2 (AtNSRV2) and Sclerotinia sclerotiorum negative-stranded RNA virus 5 (SsNSRV5) but distantly related to the members of the family\n Phenuiviridae\n . FaMBV1 could be vertically transmitted by asexual spores with lower efficiency (16.7%, 2/42). Comparison between FaMBV1-free and -infected fungal strains revealed that FaMBV1 has little effect on hyphal growth, pathogenicity, and conidium production, and its M segment is dispensable for viral replication and lost during subculture and asexual conidiation. The M and S segments of AtNSRV2 and SsNSRV5 were found using bioinformatics methods, indicating that the two fungal NSRVs harbor trisegmented genomes. Our results provide a new example of the existence and evolution of the segmented negative-sense RNA viruses in fungi.\n \n \n IMPORTANCE\n Fungal segmented negative-sense RNA viruses (SNSRVs) have been frequently found. Only the large segment encoding RNA-dependent RNA polymerase (RdRp) has been reported in most fungal SNSRVs, except for a few fungal SNSRVs reported to encode nucleocapsids, nonstructural proteins, or movement proteins. Virome analysis of the\n Fusarium\n spp. that cause\n Fusarium\n head blight discovered a novel virus, Fusarium asiaticum mycobunyavirus 1 (FaMBV1), representing a novel lineage of the family\n Phenuiviridae\n . FaMBV1 harbors a trisegmented genome that putatively encodes RdRp, glycoproteins, and nucleocapsids. The putative glycoprotein was first described in fungal SNSRVs and shared homology with glycoprotein of animal phenuivirus but was dispensable for its replication in\n F. asiaticum\n . Two other trisegmented fungal SNSRVs that also encode glycoproteins were discovered, implying that three-segment bunyavirus infections may be common in fungi. These findings provide new insights into the ecology and evolution of SNSRVs, particularly those infecting fungi.","container-title":"Journal of Virology","DOI":"10.1128/jvi.01381-22","ISSN":"0022-538X, 1098-5514","issue":"1","journalAbbreviation":"J Virol","language":"en","page":"e01381-22","source":"DOI.org (Crossref)","title":"Discovery and Characterization of Putative Glycoprotein-Encoding Mycoviruses in the <i>Bunyavirales</i>","volume":"97","author":[{"family":"Huang","given":"Huang"},{"family":"Hua","given":"Xiangmin"},{"family":"Pang","given":"Xidan"},{"family":"Zhang","given":"Zhongmei"},{"family":"Ren","given":"Jingyi"},{"family":"Cheng","given":"Jiasen"},{"family":"Fu","given":"Yanping"},{"family":"Xiao","given":"Xueqiong"},{"family":"Lin","given":"Yang"},{"family":"Chen","given":"Tao"},{"family":"Li","given":"Bo"},{"family":"Liu","given":"Huiquan"},{"family":"Jiang","given":"Daohong"},{"family":"Xie","given":"Jiatao"}],"editor":[{"family":"Parrish","given":"Colin R."}],"issued":{"date-parts":[["2023",1,31]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [18]. The L segment encodes an RNA-dependent RNA polymerase (RdRp) featuring an ovarian tumor (OTU)-like protease domain that may modulate host immune responses ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"vqa1Ul0T","properties":{"formattedCitation":"\\super [19]\\nosupersub{}","plainCitation":"[19]","noteIndex":0},"citationItems":[{"id":4484,"uris":["http://zotero.org/users/8987489/items/MI9AU78V"],"itemData":{"id":4484,"type":"article-journal","abstract":"Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus, and zoonosis, and affects large regions of Asia, Southwestern and Southeastern Europe, and Africa. CCHFV can produce symptoms, including no specific clinical symptoms, mild to severe clinical symptoms, or deadly infections. Virus isolation attempts, antigen-capture enzyme-linked immunosorbent assay (ELISA), and reverse transcription polymerase chain reaction (RT-PCR) are all possible diagnostic tests for CCHFV. Furthermore, an efficient, quick, and cheap technology, including biosensors, must be designed and developed to detect CCHFV. The goal of this article is to offer an overview of modern laboratory tests available as well as other innovative detection methods such as biosensors for CCHFV, as well as the benefits and limits of the assays. Furthermore, confirmed cases of CCHF are managed with symptomatic assistance and general supportive care. This study examined the various treatment modalities, as well as their respective limitations and developments, including immunotherapy and antivirals. Recent biotechnology advancements and the availability of suitable animal models have accelerated the development of CCHF vaccines by a substantial margin. We examined a range of potential vaccines for CCHF in this research, comprising nucleic acid, viral particles, inactivated, and multi-epitope vaccines, as well as the present obstacles and developments in this field. Thus, the purpose of this review is to present a comprehensive summary of the endeavors dedicated to advancing various diagnostic, therapeutic, and preventive strategies for CCHF infection in anticipation of forthcoming hazards.","container-title":"Biological Procedures Online","DOI":"10.1186/s12575-024-00244-3","ISSN":"1480-9222","issue":"1","journalAbbreviation":"Biological Procedures Online","page":"20","source":"BioMed Central","title":"Recent Advances in Crimean-Congo Hemorrhagic Fever Virus Detection, Treatment, and Vaccination: Overview of Current Status and Challenges","title-short":"Recent Advances in Crimean-Congo Hemorrhagic Fever Virus Detection, Treatment, and Vaccination","volume":"26","author":[{"family":"Muzammil","given":"Khursheed"},{"family":"Rayyani","given":"Saba"},{"family":"Abbas Sahib","given":"Ahmed"},{"family":"Gholizadeh","given":"Omid"},{"family":"Naji Sameer","given":"Hayder"},{"family":"Jwad Kazem","given":"Tareq"},{"family":"Badran Mohammed","given":"Haneen"},{"family":"Ghafouri Kalajahi","given":"Hesam"},{"family":"Zainul","given":"Rahadian"},{"family":"Yasamineh","given":"Saman"}],"issued":{"date-parts":[["2024",6,26]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [19].These genomic features underline the complexity of CCHFV replication and pathogenicity. Comparative analyses have revealed significant genetic variability among isolates, with phylogenetic studies clustering CCHFV into seven major clades that are geographically distinct ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"dOIQBAby","properties":{"formattedCitation":"\\super [20]\\nosupersub{}","plainCitation":"[20]","noteIndex":0},"citationItems":[{"id":4489,"uris":["http://zotero.org/users/8987489/items/G5XEBGC8"],"itemData":{"id":4489,"type":"article-journal","container-title":"Virus Research","DOI":"10.1016/j.virusres.2003.12.035","ISSN":"01681702","issue":"2","journalAbbreviation":"Virus Research","language":"en","license":"https://www.elsevier.com/tdm/userlicense/1.0/","page":"185-189","source":"DOI.org (Crossref)","title":"Crimean-Congo haemorrhagic fever virus: sequence analysis of the small RNA segments from a collection of viruses world wide","title-short":"Crimean-Congo haemorrhagic fever virus","volume":"102","author":[{"family":"Hewson","given":"R"},{"family":"Chamberlain","given":"J"},{"family":"Mioulet","given":"V"},{"family":"Lloyd","given":"G"},{"family":"Jamil","given":"B"},{"family":"Hasan","given":"R"},{"family":"Gmyl","given":"A"},{"family":"Gmyl","given":"L"},{"family":"Smirnova","given":"S.E"},{"family":"Lukashev","given":"A"},{"family":"Karganova","given":"G"},{"family":"Clegg","given":"C"}],"issued":{"date-parts":[["2004",6]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [20]. This heterogeneity has critical implications for both diagnosis and vaccine development, as it suggests that antigenic variability might affect the performance of serological assays and the breadth of vaccine-induced immunity.Advances in Molecular DiagnosticsRecent advancements in molecular diagnostics have been pivotal in improving the early detection of CCHFV. Real-time quantitative RT-PCR remains the gold standard for detecting viral RNA during the acute phase of infection ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"Y0GN9xa5","properties":{"formattedCitation":"\\super [21,22]\\nosupersub{}","plainCitation":"[21,22]","noteIndex":0},"citationItems":[{"id":4492,"uris":["http://zotero.org/users/8987489/items/N4NQ79S9"],"itemData":{"id":4492,"type":"article-journal","container-title":"Heliyon","DOI":"10.1016/j.heliyon.2017.e00353","ISSN":"24058440","issue":"7","journalAbbreviation":"Heliyon","language":"en","page":"e00353","source":"DOI.org (Crossref)","title":"Combination of RT-PCR and proteomics for the identification of Crimean-Congo hemorrhagic fever virus in ticks","volume":"3","author":[{"family":"Fernández De Mera","given":"Isabel G."},{"family":"Chaligiannis","given":"Ilias"},{"family":"Hernández-Jarguín","given":"Angélica"},{"family":"Villar","given":"Margarita"},{"family":"Mateos-Hernández","given":"Lourdes"},{"family":"Papa","given":"Anna"},{"family":"Sotiraki","given":"Smaragda"},{"family":"Ruiz-Fons","given":"Francisco"},{"family":"Cabezas-Cruz","given":"Alejandro"},{"family":"Gortázar","given":"Christian"},{"family":"De La Fuente","given":"José"}],"issued":{"date-parts":[["2017",7]]}}},{"id":4516,"uris":["http://zotero.org/users/8987489/items/QZHBN6NC"],"itemData":{"id":4516,"type":"article-journal","abstract":"Crimean–Congo hemorrhagic fever (CCHF) is a severe hemorrhagic fever in humans with a case fatality rate of up to 50%. A causative agent of CCHF is CCHF virus, which is a tick-borne virus in the family Bunyaviridae, genus Nairovirus. The virus is transmitted to humans through infected tick bites, squashed ticks or from direct contact with viremic animals or humans. Outbreaks of CCHF have been documented in Africa, the Middle East, Eastern Europe and Western Asia where the vector and/or reservoir ticks of Hyalomma spp. are distributed. Recent advances in molecular and biochemical analyses of CCHF virus revealed that the virus encodes larger proteins compared to other genus of Bunyavirus and the processing of viral proteins are complicated. Recent studies also showed that the CCHF viruses are relatively divergent in its genome sequence and the viruses are grouped in seven different clades. In general, these phylogenetic analyses based on sequences of S-RNA and L-RNA segment of CCHF viruses indicate that the seven clades correlate with their geographical location. The phylogenetic topology based on M-RNA segment sequences of CCHF viruses is different from those based on S-RNA and L-RNA segments. These analyses indicate that M-RNA segment reassortment events occur more frequently than those in S- and L-RNA segments.\nRésumé\nLa fièvre hémorragique de Crimée–Congo (FHCC) est une fièvre hémorragique foudroyante qui s’attaque à l’homme et entraîne la mort dans 50% des cas. L’agent responsable de la FHCC est un virus de type Nairovirus de la famille des Bunyaviridae qui se transmet par les tiques. Ce virus est transmis aux hommes lors de la morsure d’une tique infectée, par une tique écrasée ou par contact direct avec des animaux ou des personnes infecté(e)s. Les tiques Hyalomma spp. ont joué le rôle de vecteur et/ou de réservoir en répandant la FHCC en Afrique, au Moyen Orient, en Europe de l’Est et en Asie occidentale. Les récentes découvertes en matière d’analyses moléculaires et biochimiques sur le virus de la FHCC ont révélé qu’il encodait des protéines plus grosses que celles des autres virus de la famille des Bunyavirus, et que la fabrication des protéines virales était compliqué. De récentes études ont également montré que la séquence génomique des virus de la FHCC était assez différente, et que les virus étaient répartis en sept clades. En général, les analyses phylogénétiques, basées sur des séquences de segment d’ARN court et long des virus de la FHCC, indiquent que les sept clades sont liées à leur situation géographique. La topologie phylogénétique, basée sur les séquences du segment d’ARN moyen des virus de la FHCC, diffère de celle basée sur les segments d’ARN court et long. Ces analyses montrent que les évènements de réassortiment du segment d’ARN moyen se produisent plus fréquemment que ceux des segments d’ARN court et long.","collection-title":"Special Issue: Recent research progress on emerging infectious diseases in Asia and Oceania","container-title":"Comparative Immunology, Microbiology and Infectious Diseases","DOI":"10.1016/j.cimid.2007.07.001","ISSN":"0147-9571","issue":"5","journalAbbreviation":"Comparative Immunology, Microbiology and Infectious Diseases","page":"375-389","source":"ScienceDirect","title":"Recent progress in molecular biology of Crimean–Congo hemorrhagic fever","volume":"30","author":[{"family":"Morikawa","given":"Shigeru"},{"family":"Saijo","given":"Masayuki"},{"family":"Kurane","given":"Ichiro"}],"issued":{"date-parts":[["2007",9,1]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [21,22]. Several RT-PCR protocols have been optimized for sensitivity and specificity, enabling the detection of as few as 1000 genome equivalents per reaction. This is particularly important in resource-limited settings like Afghanistan, where early diagnosis can significantly reduce mortality rates ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"J4YavsNS","properties":{"formattedCitation":"\\super [23]\\nosupersub{}","plainCitation":"[23]","noteIndex":0},"citationItems":[{"id":4494,"uris":["http://zotero.org/users/8987489/items/DFSIH8YA"],"itemData":{"id":4494,"type":"article","abstract":"Withdrawal Statement\n The authors have withdrawn their manuscript owing to lack of approval by provincial health authorities to publish this work. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author.","DOI":"10.1101/2023.11.28.23299125","language":"en","publisher":"Infectious Diseases (except HIV/AIDS)","source":"DOI.org (Crossref)","title":"WITHDRAWN: Genomic characterization of Crimean-Congo Hemorrhagic Fever Virus detected during nosocomial outbreak (2023) in Balochistan province of Pakistan","title-short":"WITHDRAWN","URL":"http://medrxiv.org/lookup/doi/10.1101/2023.11.28.23299125","author":[{"family":"Umair","given":"Massab"},{"family":"Haider","given":"Syed Adnan"},{"family":"Ali","given":"Qasim"},{"family":"Hakim","given":"Rabia"},{"family":"Raisani","given":"Maqbool Ahmed"},{"family":"Ayub","given":"Adnan"},{"family":"Salman","given":"Muhammad"}],"accessed":{"date-parts":[["2025",3,24]]},"issued":{"date-parts":[["2023",11,29]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [23].In addition to RT-PCR, antigen capture enzyme-linked immunosorbent assays (ELISAs) targeting the NP have been developed to detect viral proteins directly in serum and tick specimens ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"d8GoTRnl","properties":{"formattedCitation":"\\super [24]\\nosupersub{}","plainCitation":"[24]","noteIndex":0},"citationItems":[{"id":4495,"uris":["http://zotero.org/users/8987489/items/UYQCNXBC"],"itemData":{"id":4495,"type":"article-journal","abstract":"Abstract\n Crimean-Congo hemorrhagic fever (CCHF) virus, a highly pathogenic viral agent is responsible for severe fatal hemorrhagic infections in many parts of the world. The early diagnosis of CCHF infection is important for successful clinical management and epidemiological control. The nucleoprotein (NP) of CCHFV being highly conserved and immunogenic is used as early diagnostic marker. In this study, we report a rapid and sensitive double antibody based antigen capture ELISA to detect Crimean-Congo hemorrhagic fever virus (CCHFV). Highly specific polyclonal and monoclonal antibody against NP has been generated and used as capture and detector antibody respectively. The assay was able to detect viral nucleoprotein in different matrices including human serum, ticks and culture supernatant. The detection limit of the developed sandwich ELISA assay was 25 ng of purified antigen. Comparison with a real time RT-PCR revealed its detection limit to be 1000 genome equivalents of CCHFV. Further the assay was comparatively evaluated with a commercial kit employing gamma irradiated CCHFV, revealing a sensitivity and specificity of 100%. This newly developed sandwich ELISA (sELISA) with high sensitivity and specificity could be used as an efficient method for the detection of CCHF virus in humans, ticks and culture supernatant. The assay will be useful as alternate tool for diagnosis of acute infection and is amenable for screening of large scale samples in resource limited settings.","container-title":"Scientific Reports","DOI":"10.1038/s41598-021-93319-0","ISSN":"2045-2322","issue":"1","journalAbbreviation":"Sci Rep","language":"en","page":"14699","source":"DOI.org (Crossref)","title":"Development of double antibody sandwich ELISA as potential diagnostic tool for rapid detection of Crimean-Congo hemorrhagic fever virus","volume":"11","author":[{"family":"Shrivastava","given":"Neha"},{"family":"Kumar","given":"Jyoti S."},{"family":"Yadav","given":"Pragya"},{"family":"Shete","given":"Anita M."},{"family":"Jain","given":"Rajlaxmi"},{"family":"Shrivastava","given":"Ambuj"},{"family":"Dash","given":"Paban Kumar"}],"issued":{"date-parts":[["2021",7,19]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [24]. These assays benefit from the high conservation and immunogenicity of the NP, providing a reliable alternative for rapid screening. Furthermore, recent studies have explored biosensor technologies, such as those utilizing nanomaterials and immunosensors, to offer rapid, on-site detection of CCHFV antigens ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"N17iBFSw","properties":{"formattedCitation":"\\super [21]\\nosupersub{}","plainCitation":"[21]","noteIndex":0},"citationItems":[{"id":4492,"uris":["http://zotero.org/users/8987489/items/N4NQ79S9"],"itemData":{"id":4492,"type":"article-journal","container-title":"Heliyon","DOI":"10.1016/j.heliyon.2017.e00353","ISSN":"24058440","issue":"7","journalAbbreviation":"Heliyon","language":"en","page":"e00353","source":"DOI.org (Crossref)","title":"Combination of RT-PCR and proteomics for the identification of Crimean-Congo hemorrhagic fever virus in ticks","volume":"3","author":[{"family":"Fernández De Mera","given":"Isabel G."},{"family":"Chaligiannis","given":"Ilias"},{"family":"Hernández-Jarguín","given":"Angélica"},{"family":"Villar","given":"Margarita"},{"family":"Mateos-Hernández","given":"Lourdes"},{"family":"Papa","given":"Anna"},{"family":"Sotiraki","given":"Smaragda"},{"family":"Ruiz-Fons","given":"Francisco"},{"family":"Cabezas-Cruz","given":"Alejandro"},{"family":"Gortázar","given":"Christian"},{"family":"De La Fuente","given":"José"}],"issued":{"date-parts":[["2017",7]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [21].Molecular Epidemiology and Phylogenetics in AfghanistanThe integration of molecular techniques into epidemiological surveillance has provided valuable insights into the spread and evolution of CCHFV in Afghanistan. Sahak et al. reported that Afghanistan has witnessed a significant increase in CCHF cases over the past decade, with a case fatality ratio of 43.3% between 2016 and 2018 ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"nJGQcrXe","properties":{"formattedCitation":"\\super [25]\\nosupersub{}","plainCitation":"[25]","noteIndex":0},"citationItems":[{"id":4496,"uris":["http://zotero.org/users/8987489/items/R24JHZ7G"],"itemData":{"id":4496,"type":"article-journal","container-title":"International Journal of Infectious Diseases","DOI":"10.1016/j.ijid.2019.08.016","ISSN":"12019712","journalAbbreviation":"International Journal of Infectious Diseases","language":"en","page":"135-140","source":"DOI.org (Crossref)","title":"Descriptive epidemiology of Crimean-Congo Hemorrhagic Fever (CCHF) in Afghanistan: Reported cases to National Surveillance System, 2016–2018","title-short":"Descriptive epidemiology of Crimean-Congo Hemorrhagic Fever (CCHF) in Afghanistan","volume":"88","author":[{"family":"Sahak","given":"Mohammad Nadir"},{"family":"Arifi","given":"Fatima"},{"family":"Saeedzai","given":"Sayed Ataullah"}],"issued":{"date-parts":[["2019",11]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [25]. Molecular epidemiology studies from Pakistan, employing sequencing of the S, M, and L segments, have revealed that this region isolates cluster with both Asian and African lineages, suggesting historical reassortment and cross-border transmission events ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"ZiqQLbJN","properties":{"formattedCitation":"\\super [26]\\nosupersub{}","plainCitation":"[26]","noteIndex":0},"citationItems":[{"id":4500,"uris":["http://zotero.org/users/8987489/items/8KVTSMZB"],"itemData":{"id":4500,"type":"article","abstract":"Pakistan is an endemic country for Crimean-Congo hemorrhagic fever (CCHF) and its Balochistan province is considered a hotspot region for circulation of the virus. This study provides a comprehensive genomic characterization of the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) associated with a nosocomial outbreak in Balochistan, Pakistan, in November 2023. Out of fourteen positive samples (n=14) processed for whole-genome sequencing, ten (n=10) samples were successfully sequenced. The phylogenetic analysis of small (S), medium (M), and large (L) segments revealed that the strains in this study are classified within the Asia-1 genotype, specifically Clade IVa. The analysis revealed a high degree of similarity (approximately 99% at the nucleotide level) between these sequences and previously reported strains circulating in Pakistan from 2017-2020, 2022, and 2023. The sequences showed close homology with CCHFV strains from neighboring countries, particularly Afghanistan, Iran, Oman, and India. Detailed mutation analysis of the sequenced samples showed unique mutations, particularly in the M (n=05) and L-segments (n=07), suggesting potential implications for the virus’s biological characteristics and epidemiology. This study highlights the need for continuous genomic surveillance to understand the evolution and adaptability of CCHFV in the region and underscores the importance of robust public health measures to control the spread of CCHF in Pakistan.","DOI":"10.1101/2023.11.28.23299125","language":"en","license":"© 2023, Posted by Cold Spring Harbor Laboratory. This pre-print is available under a Creative Commons License (Attribution-NoDerivs 4.0 International), CC BY-ND 4.0, as described at http://creativecommons.org/licenses/by-nd/4.0/","note":"page: 2023.11.28.23299125","publisher":"medRxiv","source":"medRxiv","title":"Genomic characterization of Crimean-Congo Hemorrhagic Fever Virus detected during nosocomial outbreak (2023) in Balochistan province of Pakistan","URL":"https://www.medrxiv.org/content/10.1101/2023.11.28.23299125v1","author":[{"family":"Umair","given":"Massab"},{"family":"Haider","given":"Syed Adnan"},{"family":"Ali","given":"Qasim"},{"family":"Hakim","given":"Rabia"},{"family":"Raisani","given":"Maqbool Ahmed"},{"family":"Ayub","given":"Adnan"},{"family":"Salman","given":"Muhammad"}],"accessed":{"date-parts":[["2025",3,24]]},"issued":{"date-parts":[["2023",11,29]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [26].These findings underscore the importance of molecular surveillance in identifying emerging variants and potential hotspots for CCHFV transmission. Notably, the application of next-generation sequencing (NGS) has enabled researchers to characterize the viral quasispecies present in clinical samples, thus providing a more nuanced understanding of intra-host viral diversity and evolution ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"dPlIvMsr","properties":{"formattedCitation":"\\super [27]\\nosupersub{}","plainCitation":"[27]","noteIndex":0},"citationItems":[{"id":4501,"uris":["http://zotero.org/users/8987489/items/CA2A66A3"],"itemData":{"id":4501,"type":"article-journal","abstract":"Surveillance systems that monitor pathogen genome sequences are critical for rapidly detecting the introduction and emergence of pathogen variants. To evaluate how interactions between surveillance capacity, variant properties, and the epidemiological context influence the timeliness of pathogen variant detection, we developed a geographically explicit stochastic compartmental model to simulate the transmission of a novel SARS-CoV-2 variant in New York City. We measured the impact of (1) testing and sequencing volume, (2) geographic targeting of testing, (3) the timing and location of variant emergence, and (4) the relative variant transmissibility on detection speed and on the undetected disease burden. Improvements in detection times and reduction of undetected infections were driven primarily by increases in the number of sequenced samples. The relative transmissibility of the new variant and the epidemic context of variant emergence also influenced detection times, showing that individual surveillance strategies can result in a wide range of detection outcomes, depending on the underlying dynamics of the circulating variants. These findings help contextualize the design, interpretation, and trade-offs of genomic surveillance strategies of pandemic respiratory pathogens.","container-title":"PLOS Computational Biology","DOI":"10.1371/journal.pcbi.1012416","ISSN":"1553-7358","issue":"9","journalAbbreviation":"PLoS Comput Biol","language":"en","page":"e1012416","source":"DOI.org (Crossref)","title":"Surveillance strategies for the detection of new pathogen variants across epidemiological contexts","volume":"20","author":[{"family":"Oliveira Roster","given":"Kirstin I."},{"family":"Kissler","given":"Stephen M."},{"family":"Omoregie","given":"Enoma"},{"family":"Wang","given":"Jade C."},{"family":"Amin","given":"Helly"},{"family":"Di Lonardo","given":"Steve"},{"family":"Hughes","given":"Scott"},{"family":"Grad","given":"Yonatan H."}],"editor":[{"family":"Ouzounis","given":"Christos A."}],"issued":{"date-parts":[["2024",9,5]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [27]. Such detailed molecular data are invaluable for tracking outbreaks and informing public health interventions.Novel Therapeutic and Vaccination StrategiesThe development of effective antiviral therapies and vaccines for CCHF remains a major challenge. To date, the mainstay of treatment is supportive care, with ribavirin being used off-label despite mixed evidence regarding its efficacy ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"bFR1FtjV","properties":{"formattedCitation":"\\super [28]\\nosupersub{}","plainCitation":"[28]","noteIndex":0},"citationItems":[{"id":4502,"uris":["http://zotero.org/users/8987489/items/E5GSJBBQ"],"itemData":{"id":4502,"type":"article-journal","container-title":"Infectious Disorders - Drug Targets","DOI":"10.2174/1871526517666170117125733","ISSN":"18715265","issue":"2","journalAbbreviation":"IDDT","language":"en","source":"DOI.org (Crossref)","title":"Crimean-Congo Hemorrhagic Fever Virus in Pakistan","URL":"http://www.eurekaselect.com/149352/article","volume":"17","author":[{"family":"Ijaz","given":"Muhammad"},{"family":"Rahim","given":"Afaq"},{"family":"Ali","given":"Iftikhar"}],"accessed":{"date-parts":[["2025",3,24]]},"issued":{"date-parts":[["2017",7,25]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [28]. Recent molecular studies have focused on identifying viral targets for antiviral intervention, such as the OTU protease domain within the L protein, which plays a role in modulating host immune responses ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"aCYflq8X","properties":{"formattedCitation":"\\super [29]\\nosupersub{}","plainCitation":"[29]","noteIndex":0},"citationItems":[{"id":4503,"uris":["http://zotero.org/users/8987489/items/7L78KL3N"],"itemData":{"id":4503,"type":"article-journal","abstract":"Vaccines and therapeutics targeting viral surface glycoproteins are a major component of disease prevention for respiratory viral diseases. Over the years, vaccines have proven to be the most successful intervention for preventing disease. Technological advances in vaccine platforms that focus on viral surface glycoproteins have provided solutions for current and emerging pathogens like SARS-CoV-2, and our understanding of the structural basis for antibody neutralization is guiding the selection of other vaccine targets for respiratory viruses like RSV. This review discusses the role of viral surface glycoproteins in disease intervention approaches.","container-title":"Viruses","DOI":"10.3390/v13040625","ISSN":"1999-4915","issue":"4","journalAbbreviation":"Viruses","language":"en","license":"https://creativecommons.org/licenses/by/4.0/","page":"625","source":"DOI.org (Crossref)","title":"Intervention Strategies for Seasonal and Emerging Respiratory Viruses with Drugs and Vaccines Targeting Viral Surface Glycoproteins","volume":"13","author":[{"family":"Tripp","given":"Ralph A."},{"family":"Stambas","given":"John"}],"issued":{"date-parts":[["2021",4,6]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [29].On the vaccination front, innovative strategies such as alphavirus-based replicon RNA vaccines and virus-like particle (VLP) vaccines are under investigation ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"QQBsAtf8","properties":{"formattedCitation":"\\super [30]\\nosupersub{}","plainCitation":"[30]","noteIndex":0},"citationItems":[{"id":4505,"uris":["http://zotero.org/users/8987489/items/S28I94CM"],"itemData":{"id":4505,"type":"article-journal","container-title":"International Journal of Biological Macromolecules","DOI":"10.1016/j.ijbiomac.2024.136996","ISSN":"01418130","journalAbbreviation":"International Journal of Biological Macromolecules","language":"en","page":"136996","source":"DOI.org (Crossref)","title":"Antiviral drug development by targeting RNA binding site, oligomerization and nuclear export of influenza nucleoprotein","volume":"282","author":[{"family":"Panthi","given":"Sankar"},{"family":"Hong","given":"Jhen-Yi"},{"family":"Satange","given":"Roshan"},{"family":"Yu","given":"Ching-Ching"},{"family":"Li","given":"Long-Yuan"},{"family":"Hou","given":"Ming-Hon"}],"issued":{"date-parts":[["2024",12]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [30]. Experimental data indicate that vaccines eliciting both humoral and cellular immune responses—particularly those targeting NP in combination with GPC—may offer robust protection against lethal challenge in animal models.Implications for CCHF Management in AfghanistanAfghanistan’s epidemiological profile—with its high incidence of CCHF, limited diagnostic capacity, and substantial occupational risk factors—necessitates the integration of molecular advances into public health practice. The deployment of RT-PCR and antigen-based rapid diagnostic tests in regional laboratories could facilitate timely case identification, thereby reducing the high case fatality rate observed in recent outbreaks [2, 9]. Moreover, molecular epidemiological studies can inform targeted interventions, such as vector control measures and risk communication strategies, especially among high-risk groups such as shepherds, butchers, and healthcare workers.The challenges faced by Afghanistan include not only the need for improved laboratory infrastructure but also the development of localized diagnostic kits that take into account the genetic diversity of circulating CCHFV strains. In this context, training healthcare personnel in molecular diagnostic techniques and ensuring the availability of reagents are critical steps. Additionally, collaborations with international research institutions can help bridge gaps in expertise and resource availability, ultimately leading to better outbreak preparedness and response.Table 2. Summary of Key Molecular Advances in CCHF and Their ImplicationsThemeKey FindingsImplicationsGenomic and Proteomic InsightsCCHFV has a tripartite RNA genome (S, M, L segments). Significant genetic variability among isolates, with seven major phylogenetic clades. NP, GPC, and RdRp identified as key molecular components.Genetic variability may impact vaccine efficacy and diagnostic sensitivity. Understanding viral proteins can aid in antiviral drug targeting.Molecular DiagnosticsRT-PCR remains the gold standard for CCHFV detection. Antigen capture ELISAs target nucleoprotein (NP) for rapid screening. Emerging biosensor-based technologies for point-of-care testing.Early detection improves patient outcomes. Field-deployable diagnostic tools can enhance outbreak surveillance in Afghanistan.Molecular Epidemiology & PhylogeneticsAfghanistan has seen a rise in CCHF cases, with a case fatality ratio of 43.3%. Cross-border transmission with Asian and African lineages detected. NGS reveals viral quasispecies diversity.Molecular surveillance is crucial for tracking outbreak sources and viral evolution. Helps in developing region-specific diagnostic assays and vaccines.Therapeutic & Vaccination StrategiesRibavirin used off-label with inconsistent efficacy. OTU protease domain identified as a potential antiviral target. Novel vaccine candidates include RNA replicons and VLPs.Limited treatment options highlight the need for targeted antivirals. Broad-spectrum vaccine strategies should address CCHFV’s genetic diversity.Public Health Implications for AfghanistanLimited diagnostic infrastructure hinders rapid case identification. High-risk occupations (livestock handlers, butchers, healthcare workers) contribute to disease burden. International collaborations needed to enhance molecular research capacity.Establishing regional RT-PCR and antigen-based rapid tests can improve case detection. Training programs for healthcare personnel on molecular diagnostics are essential. Strengthening partnerships with global virology research centers can bridge gaps in expertise and technology.Table 2 provides a structured summary of the molecular advances in CCHFV research, highlighting genomic insights, diagnostics, epidemiology, therapeutic strategies, and public health implications. These findings underscore the importance of molecular techniques in improving disease management and outbreak control, particularly in Afghanistan, where laboratory resources remain limited. The review emphasizes the urgent need for region-specific diagnostic tools, enhanced surveillance, and investment in vaccine development.DiscussionThe advent of advanced molecular techniques has revolutionized infectious disease diagnostics. In the case of CCHF, rapid detection of viral RNA and genetic characterization have provided critical insights into viral transmission and evolution. In Afghanistan, where traditional surveillance is hindered by limited laboratory capacity, integrating molecular diagnostics could significantly improve outbreak detection and control. Recent studies in Herat Province (2017) demonstrated a 22.2% case fatality rate (CFR) among hospitalized patients, underscoring the urgent need for early diagnosis and improved surveillance systems ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"tjBmGWq5","properties":{"formattedCitation":"\\super [31]\\nosupersub{}","plainCitation":"[31]","noteIndex":0},"citationItems":[{"id":4769,"uris":["http://zotero.org/users/8987489/items/BPINKFL6"],"itemData":{"id":4769,"type":"article-journal","abstract":"Crimean-Congo Hemorrhagic Fever, Herat Province, Afghanistan, 2017","DOI":"10.3201/eid2508.181491","language":"en-us","source":"wwwnc.cdc.gov","title":"Crimean-Congo Hemorrhagic Fever, Herat Province, Afghanistan, 2017 - Volume 25, Number 8—August 2019 - Emerging Infectious Diseases journal - CDC","URL":"https://wwwnc.cdc.gov/eid/article/25/8/18-1491_article","author":[{"family":"Niazi","given":"Aziz-ur-Rahman"},{"family":"Jawad","given":"Mohammad Jawed"},{"family":"Amirnajad","given":"Ahmad"},{"family":"Durr","given":"Peter A."},{"family":"Williams","given":"David T."}],"accessed":{"date-parts":[["2025",4,15]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [31].Our review highlights that RT-PCR remains the cornerstone of CCHFV diagnosis ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"TXXmoEBk","properties":{"formattedCitation":"\\super [5]\\nosupersub{}","plainCitation":"[5]","noteIndex":0},"citationItems":[{"id":4471,"uris":["http://zotero.org/users/8987489/items/69Q4FBVK","http://zotero.org/users/8987489/items/5BQ22A69"],"itemData":{"id":4471,"type":"article-journal","container-title":"Laboratory Medicine","DOI":"10.1309/LMN1P2FRZ7BKZSCO","ISSN":"0007-5027, 1943-7730","issue":"3","journalAbbreviation":"Lab Med","language":"en","page":"180-189","source":"DOI.org (Crossref)","title":"Crimean-Congo Hemorrhagic Fever","volume":"46","author":[{"family":"Shayan","given":"Sara"},{"family":"Bokaean","given":"Mohammad"},{"family":"Shahrivar","given":"Mona Ranjvar"},{"family":"Chinikar","given":"Sadegh"}],"issued":{"date-parts":[["2015",8,1]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [5], though deployment in field settings is often challenged by infrastructural limitations. Biosensor-based diagnostic tools, still in the experimental phase, show promise as rapid, cost-effective alternatives for resource-limited regions ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"2GBGT5Y0","properties":{"formattedCitation":"\\super [5]\\nosupersub{}","plainCitation":"[5]","noteIndex":0},"citationItems":[{"id":4471,"uris":["http://zotero.org/users/8987489/items/69Q4FBVK","http://zotero.org/users/8987489/items/5BQ22A69"],"itemData":{"id":4471,"type":"article-journal","container-title":"Laboratory Medicine","DOI":"10.1309/LMN1P2FRZ7BKZSCO","ISSN":"0007-5027, 1943-7730","issue":"3","journalAbbreviation":"Lab Med","language":"en","page":"180-189","source":"DOI.org (Crossref)","title":"Crimean-Congo Hemorrhagic Fever","volume":"46","author":[{"family":"Shayan","given":"Sara"},{"family":"Bokaean","given":"Mohammad"},{"family":"Shahrivar","given":"Mona Ranjvar"},{"family":"Chinikar","given":"Sadegh"}],"issued":{"date-parts":[["2015",8,1]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [5]. The use of double-antigen ELISA for large-scale seroprevalence studies in Afghan livestock populations (19% seropositivity in cattle, goats, and sheep) could serve as an early warning system for human outbreaks ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"iRDy47OX","properties":{"formattedCitation":"\\super [32]\\nosupersub{}","plainCitation":"[32]","noteIndex":0},"citationItems":[{"id":4771,"uris":["http://zotero.org/users/8987489/items/6LJNHVSW"],"itemData":{"id":4771,"type":"article-journal","abstract":"Crimean Congo hemorrhagic fever (CCHF) is a tick-borne, zoonotic disease which is characterized by fever and hemorrhages in humans but is asymptomatic…","container-title":"Kuwait Journal of Science","DOI":"10.1016/j.kjs.2023.09.005","ISSN":"2307-4108","issue":"1","language":"en-US","note":"publisher: Elsevier","page":"100131","source":"www.sciencedirect.com","title":"Epizootiology and seroprevalence of Crimean-Congo hemorrhagic fever virus in ruminant population of East Afghanistan","volume":"51","issued":{"date-parts":[["2024",1,1]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [32]. These technologies could be particularly beneficial in Afghanistan, where early diagnosis is crucial for reducing high CCHF mortality ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"c94fJCnv","properties":{"formattedCitation":"\\super [33]\\nosupersub{}","plainCitation":"[33]","noteIndex":0},"citationItems":[{"id":4508,"uris":["http://zotero.org/users/8987489/items/LV2T5JLX"],"itemData":{"id":4508,"type":"article-journal","abstract":"Crimean-Congo haemorrhagic fever (CCHF) is a widespread tickborne disease that circulates in wild and domestic animal hosts, and causes severe and often fatal haemorrhagic fever in infected humans. Due to the lack of treatment options or vaccines, and a high fatality rate, CCHF virus (CCHFV) is considered a high-priority pathogen according to the WHO R&D Blueprint. Several commercial reverse transcriptase PCR (RT-PCR) and serological diagnostic assays for CCHFV are already available, including febrile agent panels to distinguish CCHFV from other viral haemorrhagic fever agents; however, the majority of international laboratories use inhouse assays. As CCHFV has numerous amplifying animal hosts, a cross-sectoral ‘One Health’ approach to outbreak prevention is recommended to enhance notifications and enable early warning for genetic and epidemiological shifts in the human, animal and tick populations. However, a lack of guidance for surveillance in animals, harmonisation of case identification and validated serodiagnostic kits for animal testing hinders efforts to strengthen surveillance systems. Additionally, as RT-PCR tests tend to be lineage-specific for regional circulating strains, there is a need for pan-lineage sensitive diagnostics. Adaptation of existing tests to point-of-care molecular diagnostic platforms that can be implemented in clinic or field-based settings would be of value given the potential for CCHFV outbreaks in remote or low-resource areas. Finally, improved access to clinical specimens for validation of diagnostics would help to accelerate development of new tests. These gaps should be addressed by updated target product profiles for CCHFV diagnostics.","container-title":"BMJ Global Health","DOI":"10.1136/bmjgh-2018-001114","ISSN":"2059-7908","issue":"Suppl 2","journalAbbreviation":"BMJ Glob Health","language":"en","page":"e001114","source":"DOI.org (Crossref)","title":"Diagnostic tests for Crimean-Congo haemorrhagic fever: a widespread tickborne disease","title-short":"Diagnostic tests for Crimean-Congo haemorrhagic fever","volume":"4","author":[{"family":"Mazzola","given":"Laura T"},{"family":"Kelly-Cirino","given":"Cassandra"}],"issued":{"date-parts":[["2019",2]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [33].Genomic and proteomic analyses of CCHFV have identified several unique features among bunyaviruses. The virus’s unusually large M segment encodes a polyprotein that undergoes extensive post-translational modifications, enhancing antigenic variation and immune evasion ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"RzyjDGug","properties":{"formattedCitation":"\\super [34]\\nosupersub{}","plainCitation":"[34]","noteIndex":0},"citationItems":[{"id":4510,"uris":["http://zotero.org/users/8987489/items/PQMC2FJZ"],"itemData":{"id":4510,"type":"article-journal","abstract":"Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen that causes high morbidity and mortality. Efficacy of vaccines and antivirals to treat human CCHFV infections remains limited and controversial. Research into pathology and underlying molecular mechanisms of CCHFV and other nairoviruses is limited. Significant progress has been made in our understanding of CCHFV replication and pathogenesis in the past decade. Here we review the most recent molecular advances in CCHFV-related research, and provide perspectives on future research.","container-title":"Viruses","DOI":"10.3390/v8040106","ISSN":"1999-4915","issue":"4","journalAbbreviation":"Viruses","language":"en","license":"https://creativecommons.org/licenses/by/4.0/","page":"106","source":"DOI.org (Crossref)","title":"Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus","volume":"8","author":[{"family":"Zivcec","given":"Marko"},{"family":"Scholte","given":"Florine"},{"family":"Spiropoulou","given":"Christina"},{"family":"Spengler","given":"Jessica"},{"family":"Bergeron","given":"Éric"}],"issued":{"date-parts":[["2016",4,21]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [34]. Phylogenetic studies of Afghan and Pakistani CCHFV isolates revealed extensive genetic diversity, including reassortment events between Asia-1 and Asia-2 genogroups, complicating regional outbreak responses ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"A6l7bIBC","properties":{"formattedCitation":"\\super [35,36]\\nosupersub{}","plainCitation":"[35,36]","noteIndex":0},"citationItems":[{"id":4774,"uris":["http://zotero.org/users/8987489/items/TT6SXANV"],"itemData":{"id":4774,"type":"article-journal","abstract":"The global spread of ticks and various tick-borne viruses (TBVs) suggests the possibility of new tick-borne diseases emerging. Crimean-Congo hemorrhagic fever virus (CCHFV) is an emerging TBV of the Nairoviridae family that causes serious disease that can be fatal in humans. CCHFV endemic foci can be found in Africa, Asia, the Middle East, and South-Eastern Europe, and has spread to previously unaffected regions and nations, such as Spain, over the last two decades. In this review, we discuss the current situation of CCHFV in Asia, Africa and Europe based on existing knowledge, and we discuss driving factors in the distribution and transmission of the virus, such as the spread of tick vector species and host reservoirs.","container-title":"Microorganisms","DOI":"10.3390/microorganisms9091907","ISSN":"2076-2607","issue":"9","language":"en","license":"http://creativecommons.org/licenses/by/3.0/","note":"number: 9\npublisher: Multidisciplinary Digital Publishing Institute","page":"1907","source":"www.mdpi.com","title":"Crimean-Congo Hemorrhagic Fever Virus in Asia, Africa and Europe","volume":"9","author":[{"family":"Shahhosseini","given":"Nariman"},{"family":"Wong","given":"Gary"},{"family":"Babuadze","given":"George"},{"family":"Camp","given":"Jeremy V."},{"family":"Ergonul","given":"Onder"},{"family":"Kobinger","given":"Gary P."},{"family":"Chinikar","given":"Sadegh"},{"family":"Nowotny","given":"Norbert"}],"issued":{"date-parts":[["2021",9]]}}},{"id":4772,"uris":["http://zotero.org/users/8987489/items/IWYC4MHI"],"itemData":{"id":4772,"type":"article-journal","abstract":"Crimean-Congo Hemorrhagic Fever Virus, Pakistan","DOI":"10.3201/eid3004.231155","language":"en-us","source":"wwwnc.cdc.gov","title":"Crimean-Congo Hemorrhagic Fever Virus Diversity and Reassortment, Pakistan, 2017–2020 - Volume 30, Number 4—April 2024 - Emerging Infectious Diseases journal - CDC","URL":"https://wwwnc.cdc.gov/eid/article/30/4/23-1155_article","author":[{"family":"Umair","given":"Massab"},{"family":"Rehman","given":"Zaira"},{"family":"Whitmer","given":"Shannon"},{"family":"Mobley","given":"Melissa"},{"family":"Fahim","given":"Ammad"},{"family":"Ikram","given":"Aamer"},{"family":"Salman","given":"Muhammad"},{"family":"Montgomery","given":"Joel M."},{"family":"Klena","given":"John D."}],"accessed":{"date-parts":[["2025",4,15]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [35,36]. Additionally, the discovery of an OTU-like protease domain in the L protein has deepened our understanding of viral replication and highlighted potential antiviral targets ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"E4NUw2dt","properties":{"formattedCitation":"\\super [15]\\nosupersub{}","plainCitation":"[15]","noteIndex":0},"citationItems":[{"id":4481,"uris":["http://zotero.org/users/8987489/items/S4EQ55SG"],"itemData":{"id":4481,"type":"article-journal","container-title":"International Journal of Advanced Biochemistry Research","DOI":"10.33545/26174693.2018.v2.i1a.7","ISSN":"26174693, 26174707","issue":"1","journalAbbreviation":"Int. J. Adv. Biochem. Res.","page":"01-05","source":"DOI.org (Crossref)","title":"Review of epidemiology, diagnosis, control, therapeutics and vaccine development for Crimean-Congo hemorrhagic fever","volume":"2","author":[{"family":"Siddiqui","given":"Faizan Q"},{"family":"Parveen","given":"Ghazala"},{"family":"Hussain","given":"Shahzad"}],"issued":{"date-parts":[["2018",1,1]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [15].The genetic diversity among CCHFV isolates, particularly those from Afghanistan, suggests that multiple viral variants may drive local outbreaks. Emerging clades in northwestern Iran, adjacent to Afghanistan, highlight the cross-border spread of novel haplotypes and the need for region-specific diagnostic kits ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"cadqY50l","properties":{"formattedCitation":"\\super [37]\\nosupersub{}","plainCitation":"[37]","noteIndex":0},"citationItems":[{"id":4776,"uris":["http://zotero.org/users/8987489/items/DVY9LD25"],"itemData":{"id":4776,"type":"article-journal","abstract":"Crimean-Congo hemorrhagic fever (CCHF) is one of the most acute tick-transmitted zoonotic diseases. The purpose of this study was to determine the molecular characteristics and phylogenetic analysis of the CCHF virus based on the S-segment nucleocapsid gene in Ardabil Province, northwestern Iran. From November 2021 to May 2023, a total of 20 peripheral blood specimens were collected from suspected CCHF patients. Following RNA extraction, the partial nucleotide sequence of the S fragment was amplified (536 bp) using a one-step RT-PCR Kit. PCR products were successfully sequenced to perform phylogenetic analysis and haplotype distribution. The mean age of CCHF patients was 30.4 ± 10.45 years and all male patients had a history of tick exposure. According to molecular findings, the frequency of CCHFV in patients was 25% (5/20). A high haplotype diversity (Hd: 1; haplotype number: 5) and distinct genetic clade (IV) of CCHFV were identified among the patients in Ardabil province compared to other regions of Iran. The occurrence of new haplotypes shows new evidence of the emerging threat of the CCHFV in the region. Current findings strengthen our knowledge of transmission dynamics and dispersion of probable drug-resistant alleles of CCHFV in northwestern Iran, also it will become the basis of public health policy to control CCHF in the region. Not applicable.","container-title":"BMC Infectious Diseases","DOI":"10.1186/s12879-025-10728-6","ISSN":"1471-2334","issue":"1","journalAbbreviation":"BMC Infect Dis","language":"en","license":"2025 The Author(s)","note":"number: 1\npublisher: BioMed Central","page":"1-7","source":"bmcinfectdis.biomedcentral.com","title":"Molecular characterization and phylogenetic analysis of Crimean-Congo hemorrhagic fever virus, northwestern of Iran","volume":"25","author":[{"family":"Soozangar","given":"Narges"},{"family":"Jeddi","given":"Farhad"},{"family":"Spotin","given":"Adel"},{"family":"Molaei","given":"Soheila"},{"family":"Mohammadi-Ghalehbin","given":"Behnam"},{"family":"Habibzadeh","given":"Shahram"},{"family":"Mohammadshahi","given":"Jafar"},{"family":"Mirzanejad-Asl","given":"Hafez"},{"family":"Dogaheh","given":"Hadi Peeri"}],"issued":{"date-parts":[["2025",12]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [37]. This variability complicates vaccine development and necessitates broad-spectrum diagnostic assays. Future studies should map conserved antigenic determinants across strains to inform universal vaccine design and pan-genotypic antiviral agents ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"Vb4o0NNp","properties":{"formattedCitation":"\\super [38]\\nosupersub{}","plainCitation":"[38]","noteIndex":0},"citationItems":[{"id":4511,"uris":["http://zotero.org/users/8987489/items/5CFVQTCF"],"itemData":{"id":4511,"type":"article-journal","container-title":"Journal of Clinical Virology","DOI":"10.1016/j.jcv.2014.08.029","ISSN":"13866532","journalAbbreviation":"Journal of Clinical Virology","language":"en","page":"137-143","source":"DOI.org (Crossref)","title":"Recent advances in research on Crimean-Congo hemorrhagic fever","volume":"64","author":[{"family":"Papa","given":"Anna"},{"family":"Mirazimi","given":"Ali"},{"family":"Köksal","given":"Iftihar"},{"family":"Estrada-Pena","given":"Augustin"},{"family":"Feldmann","given":"Heinz"}],"issued":{"date-parts":[["2015",3]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [38].Despite advances in molecular virology, a licensed CCHF vaccine remains unavailable. Experimental vaccine platforms—including RNA replicons, virus-like particles (VLPs), and recombinant protein vaccines—have shown promise in preclinical models ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"Tdq7EUru","properties":{"formattedCitation":"\\super [15]\\nosupersub{}","plainCitation":"[15]","noteIndex":0},"citationItems":[{"id":4481,"uris":["http://zotero.org/users/8987489/items/S4EQ55SG"],"itemData":{"id":4481,"type":"article-journal","container-title":"International Journal of Advanced Biochemistry Research","DOI":"10.33545/26174693.2018.v2.i1a.7","ISSN":"26174693, 26174707","issue":"1","journalAbbreviation":"Int. J. Adv. Biochem. Res.","page":"01-05","source":"DOI.org (Crossref)","title":"Review of epidemiology, diagnosis, control, therapeutics and vaccine development for Crimean-Congo hemorrhagic fever","volume":"2","author":[{"family":"Siddiqui","given":"Faizan Q"},{"family":"Parveen","given":"Ghazala"},{"family":"Hussain","given":"Shahzad"}],"issued":{"date-parts":[["2018",1,1]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [15]. Preclinical studies targeting glycoproteins (Gn/Gc) and nucleoproteins have demonstrated cross-protection against diverse CCHFV clades, a critical feature given the co-circulation of Asia-1 and Asia-2 strains in Afghanistan and neighboring countries ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"OgG0kcrS","properties":{"formattedCitation":"\\super [39]\\nosupersub{}","plainCitation":"[39]","noteIndex":0},"citationItems":[{"id":4778,"uris":["http://zotero.org/users/8987489/items/GJHZA8HM"],"itemData":{"id":4778,"type":"article-journal","abstract":"The global spread of ticks and various tick-borne viruses (TBVs) suggests the possibility of new tick-borne diseases emerging. Crimean-Congo hemorrhagic fever virus (CCHFV) is an emerging TBV of the Nairoviridae family that causes serious disease that can be fatal in humans. CCHFV endemic foci can be found in Africa, Asia, the Middle East, and South-Eastern Europe, and has spread to previously unaffected regions and nations, such as Spain, over the last two decades. In this review, we discuss the current situation of CCHFV in Asia, Africa and Europe based on existing knowledge, and we discuss driving factors in the distribution and transmission of the virus, such as the spread of tick vector species and host reservoirs.","container-title":"Microorganisms","DOI":"10.3390/microorganisms9091907","ISSN":"2076-2607","issue":"9","language":"en","license":"http://creativecommons.org/licenses/by/3.0/","note":"number: 9\npublisher: Multidisciplinary Digital Publishing Institute","page":"1907","source":"www.mdpi.com","title":"Crimean-Congo Hemorrhagic Fever Virus in Asia, Africa and Europe","volume":"9","author":[{"family":"Shahhosseini","given":"Nariman"},{"family":"Wong","given":"Gary"},{"family":"Babuadze","given":"George"},{"family":"Camp","given":"Jeremy V."},{"family":"Ergonul","given":"Onder"},{"family":"Kobinger","given":"Gary P."},{"family":"Chinikar","given":"Sadegh"},{"family":"Nowotny","given":"Norbert"}],"issued":{"date-parts":[["2021",9]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [39]. Targeting both structural (glycoproteins) and non-structural (nucleoproteins) viral proteins appears to enhance immune protection, with animal models demonstrating improved survival after lethal challenge ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"WCACV8JL","properties":{"formattedCitation":"\\super [34]\\nosupersub{}","plainCitation":"[34]","noteIndex":0},"citationItems":[{"id":4510,"uris":["http://zotero.org/users/8987489/items/PQMC2FJZ"],"itemData":{"id":4510,"type":"article-journal","abstract":"Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen that causes high morbidity and mortality. Efficacy of vaccines and antivirals to treat human CCHFV infections remains limited and controversial. Research into pathology and underlying molecular mechanisms of CCHFV and other nairoviruses is limited. Significant progress has been made in our understanding of CCHFV replication and pathogenesis in the past decade. Here we review the most recent molecular advances in CCHFV-related research, and provide perspectives on future research.","container-title":"Viruses","DOI":"10.3390/v8040106","ISSN":"1999-4915","issue":"4","journalAbbreviation":"Viruses","language":"en","license":"https://creativecommons.org/licenses/by/4.0/","page":"106","source":"DOI.org (Crossref)","title":"Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus","volume":"8","author":[{"family":"Zivcec","given":"Marko"},{"family":"Scholte","given":"Florine"},{"family":"Spiropoulou","given":"Christina"},{"family":"Spengler","given":"Jessica"},{"family":"Bergeron","given":"Éric"}],"issued":{"date-parts":[["2016",4,21]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [34].Key challenges persist. First, the high genetic variability of CCHFV requires vaccines to elicit cross-protective immunity. The identification of a tick-specific glycoprotein variant with reduced human cell fusion activity underscores the need to account for vector-driven viral adaptations in vaccine design ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"8lEbbfLB","properties":{"formattedCitation":"\\super [39]\\nosupersub{}","plainCitation":"[39]","noteIndex":0},"citationItems":[{"id":4778,"uris":["http://zotero.org/users/8987489/items/GJHZA8HM"],"itemData":{"id":4778,"type":"article-journal","abstract":"The global spread of ticks and various tick-borne viruses (TBVs) suggests the possibility of new tick-borne diseases emerging. Crimean-Congo hemorrhagic fever virus (CCHFV) is an emerging TBV of the Nairoviridae family that causes serious disease that can be fatal in humans. CCHFV endemic foci can be found in Africa, Asia, the Middle East, and South-Eastern Europe, and has spread to previously unaffected regions and nations, such as Spain, over the last two decades. In this review, we discuss the current situation of CCHFV in Asia, Africa and Europe based on existing knowledge, and we discuss driving factors in the distribution and transmission of the virus, such as the spread of tick vector species and host reservoirs.","container-title":"Microorganisms","DOI":"10.3390/microorganisms9091907","ISSN":"2076-2607","issue":"9","language":"en","license":"http://creativecommons.org/licenses/by/3.0/","note":"number: 9\npublisher: Multidisciplinary Digital Publishing Institute","page":"1907","source":"www.mdpi.com","title":"Crimean-Congo Hemorrhagic Fever Virus in Asia, Africa and Europe","volume":"9","author":[{"family":"Shahhosseini","given":"Nariman"},{"family":"Wong","given":"Gary"},{"family":"Babuadze","given":"George"},{"family":"Camp","given":"Jeremy V."},{"family":"Ergonul","given":"Onder"},{"family":"Kobinger","given":"Gary P."},{"family":"Chinikar","given":"Sadegh"},{"family":"Nowotny","given":"Norbert"}],"issued":{"date-parts":[["2021",9]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [39]. Second, the absence of standardized animal models complicates efficacy testing ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"q4HJsAbi","properties":{"formattedCitation":"\\super [38]\\nosupersub{}","plainCitation":"[38]","noteIndex":0},"citationItems":[{"id":4511,"uris":["http://zotero.org/users/8987489/items/5CFVQTCF"],"itemData":{"id":4511,"type":"article-journal","container-title":"Journal of Clinical Virology","DOI":"10.1016/j.jcv.2014.08.029","ISSN":"13866532","journalAbbreviation":"Journal of Clinical Virology","language":"en","page":"137-143","source":"DOI.org (Crossref)","title":"Recent advances in research on Crimean-Congo hemorrhagic fever","volume":"64","author":[{"family":"Papa","given":"Anna"},{"family":"Mirazimi","given":"Ali"},{"family":"Köksal","given":"Iftihar"},{"family":"Estrada-Pena","given":"Augustin"},{"family":"Feldmann","given":"Heinz"}],"issued":{"date-parts":[["2015",3]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [38]. Collaborative efforts uniting virologists, immunologists, and vaccine developers are essential to accelerating clinical trials ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"ZllwY1R3","properties":{"formattedCitation":"\\super [40]\\nosupersub{}","plainCitation":"[40]","noteIndex":0},"citationItems":[{"id":4513,"uris":["http://zotero.org/users/8987489/items/QERI4M9Y"],"itemData":{"id":4513,"type":"article-journal","abstract":"The dangerous Crimean-Congo hemorrhagic fever virus (CCHFV), an encapsulated negative-sense RNA virus of the family Nairoviridae, is transmitted from person to person via ticks. With a case fatality rate between 10% to 40%, the most common ways that the disease may spread to humans are via tick bites or coming into touch with infected animals' blood or tissues. Furthermore, the transfer of bodily fluids between individuals is another potential route of infection. There is a wide range of symptoms experienced by patients throughout each stage, from myalgia and fever to extreme bruising and excess bleeding. Tick management measures include minimising the spread of ticks from one species to another and from people to animals via the use of protective clothing, repellents, and proper animal handling. In order to prevent the spread of illness, healthcare workers must adhere to stringent protocols. Despite the lack of an authorised vaccine, the main components of treatment now consist of preventative measures and supportive care, which may include the antiviral medicine ribavirin. We still don't know very much about the virus's mechanisms, even though advances in molecular virology and animal models have improved our understanding of the pathogenesis of CCHFV. A critical need for vaccination that is both safe and effective, as well as for quick diagnosis and efficient treatments to lessen the disease's impact in areas where it is most prevalent. Important steps towards lowering Crimean-Congo hemorrhagic fever mortality and morbidity rates were to anticipatethe future availability of immunoglobulin products.","container-title":"World Journal of Virology","DOI":"10.5501/wjv.v14.i1.100003","ISSN":"2220-3249","issue":"1","journalAbbreviation":"World J Virol","source":"DOI.org (Crossref)","title":"Crimean-Congo hemorrhagic fever: Pathogenesis, transmission and public health challenges","title-short":"Crimean-Congo hemorrhagic fever","URL":"https://www.wjgnet.com/2220-3249/full/v14/i1/100003.htm","volume":"14","author":[{"family":"Karanam","given":"Sita Kumari"},{"family":"Nagvishnu","given":"Kandra"},{"family":"Uppala","given":"Praveen Kumar"},{"family":"Edhi","given":"Sandhya"},{"family":"Varri","given":"Srinivasa Rao"}],"accessed":{"date-parts":[["2025",3,25]]},"issued":{"date-parts":[["2025",3,25]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [40].Epidemiological data from Afghanistan indicate a concerning rise in CCHF cases. Between 2022 and 2023, Afghanistan reported 806 cases and 86 deaths across 14 provinces, reflecting both improved detection and true incidence growth ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"XYFA7xgy","properties":{"formattedCitation":"\\super [41]\\nosupersub{}","plainCitation":"[41]","noteIndex":0},"citationItems":[{"id":4780,"uris":["http://zotero.org/users/8987489/items/KG5QVBS4"],"itemData":{"id":4780,"type":"webpage","abstract":"These Pathogen Safety Data Sheets, regulated under Workplace Hazardous Materials Information System (WHMIS) legislation, are produced for personnel working in the life sciences as quick safety reference material relating to infectious micro-organisms.","genre":"education and awareness;guidance","language":"eng","note":"Last Modified: 2024-03-11","title":"Crimean-Congo hemorrhagic fever virus: Infectious substances pathogen safety data sheet","title-short":"Crimean-Congo hemorrhagic fever virus","URL":"https://www.canada.ca/en/public-health/services/laboratory-biosafety-biosecurity/pathogen-safety-data-sheets-risk-assessment/crimean-congo-haemorrhagic-fever-virus.html","author":[{"literal":"Public Health Agency of Canada"}],"accessed":{"date-parts":[["2025",4,15]]},"issued":{"date-parts":[["2001",9,17]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [41]. With high mortality rates and limited diagnostic capacity, integrating molecular diagnostics into national surveillance is imperative ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"R3evzHq2","properties":{"formattedCitation":"\\super [33]\\nosupersub{}","plainCitation":"[33]","noteIndex":0},"citationItems":[{"id":4508,"uris":["http://zotero.org/users/8987489/items/LV2T5JLX"],"itemData":{"id":4508,"type":"article-journal","abstract":"Crimean-Congo haemorrhagic fever (CCHF) is a widespread tickborne disease that circulates in wild and domestic animal hosts, and causes severe and often fatal haemorrhagic fever in infected humans. Due to the lack of treatment options or vaccines, and a high fatality rate, CCHF virus (CCHFV) is considered a high-priority pathogen according to the WHO R&D Blueprint. Several commercial reverse transcriptase PCR (RT-PCR) and serological diagnostic assays for CCHFV are already available, including febrile agent panels to distinguish CCHFV from other viral haemorrhagic fever agents; however, the majority of international laboratories use inhouse assays. As CCHFV has numerous amplifying animal hosts, a cross-sectoral ‘One Health’ approach to outbreak prevention is recommended to enhance notifications and enable early warning for genetic and epidemiological shifts in the human, animal and tick populations. However, a lack of guidance for surveillance in animals, harmonisation of case identification and validated serodiagnostic kits for animal testing hinders efforts to strengthen surveillance systems. Additionally, as RT-PCR tests tend to be lineage-specific for regional circulating strains, there is a need for pan-lineage sensitive diagnostics. Adaptation of existing tests to point-of-care molecular diagnostic platforms that can be implemented in clinic or field-based settings would be of value given the potential for CCHFV outbreaks in remote or low-resource areas. Finally, improved access to clinical specimens for validation of diagnostics would help to accelerate development of new tests. These gaps should be addressed by updated target product profiles for CCHFV diagnostics.","container-title":"BMJ Global Health","DOI":"10.1136/bmjgh-2018-001114","ISSN":"2059-7908","issue":"Suppl 2","journalAbbreviation":"BMJ Glob Health","language":"en","page":"e001114","source":"DOI.org (Crossref)","title":"Diagnostic tests for Crimean-Congo haemorrhagic fever: a widespread tickborne disease","title-short":"Diagnostic tests for Crimean-Congo haemorrhagic fever","volume":"4","author":[{"family":"Mazzola","given":"Laura T"},{"family":"Kelly-Cirino","given":"Cassandra"}],"issued":{"date-parts":[["2019",2]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [33]. Developing region-specific diagnostic kits tailored to local CCHFV variants will be essential ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"Zt1mnpg0","properties":{"formattedCitation":"\\super [5]\\nosupersub{}","plainCitation":"[5]","noteIndex":0},"citationItems":[{"id":4471,"uris":["http://zotero.org/users/8987489/items/69Q4FBVK","http://zotero.org/users/8987489/items/5BQ22A69"],"itemData":{"id":4471,"type":"article-journal","container-title":"Laboratory Medicine","DOI":"10.1309/LMN1P2FRZ7BKZSCO","ISSN":"0007-5027, 1943-7730","issue":"3","journalAbbreviation":"Lab Med","language":"en","page":"180-189","source":"DOI.org (Crossref)","title":"Crimean-Congo Hemorrhagic Fever","volume":"46","author":[{"family":"Shayan","given":"Sara"},{"family":"Bokaean","given":"Mohammad"},{"family":"Shahrivar","given":"Mona Ranjvar"},{"family":"Chinikar","given":"Sadegh"}],"issued":{"date-parts":[["2015",8,1]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [5].International collaborations can facilitate technology transfer and capacity building in Afghanistan. Partnerships leveraging genomic surveillance networks, such as those mapping Hyalomma tick distributions in South Asia, could enhance predictive modeling of outbreak risks ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"3ma94p5S","properties":{"formattedCitation":"\\super [39]\\nosupersub{}","plainCitation":"[39]","noteIndex":0},"citationItems":[{"id":4778,"uris":["http://zotero.org/users/8987489/items/GJHZA8HM"],"itemData":{"id":4778,"type":"article-journal","abstract":"The global spread of ticks and various tick-borne viruses (TBVs) suggests the possibility of new tick-borne diseases emerging. Crimean-Congo hemorrhagic fever virus (CCHFV) is an emerging TBV of the Nairoviridae family that causes serious disease that can be fatal in humans. CCHFV endemic foci can be found in Africa, Asia, the Middle East, and South-Eastern Europe, and has spread to previously unaffected regions and nations, such as Spain, over the last two decades. In this review, we discuss the current situation of CCHFV in Asia, Africa and Europe based on existing knowledge, and we discuss driving factors in the distribution and transmission of the virus, such as the spread of tick vector species and host reservoirs.","container-title":"Microorganisms","DOI":"10.3390/microorganisms9091907","ISSN":"2076-2607","issue":"9","language":"en","license":"http://creativecommons.org/licenses/by/3.0/","note":"number: 9\npublisher: Multidisciplinary Digital Publishing Institute","page":"1907","source":"www.mdpi.com","title":"Crimean-Congo Hemorrhagic Fever Virus in Asia, Africa and Europe","volume":"9","author":[{"family":"Shahhosseini","given":"Nariman"},{"family":"Wong","given":"Gary"},{"family":"Babuadze","given":"George"},{"family":"Camp","given":"Jeremy V."},{"family":"Ergonul","given":"Onder"},{"family":"Kobinger","given":"Gary P."},{"family":"Chinikar","given":"Sadegh"},{"family":"Nowotny","given":"Norbert"}],"issued":{"date-parts":[["2021",9]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [39]. Partnerships with institutions specializing in molecular virology and biosensor diagnostics could help local laboratories adopt cutting-edge methods. Moreover, integrating molecular epidemiological data with traditional surveillance would allow for more targeted public health interventions and timely outbreak responses ADDIN ZOTERO_ITEM CSL_CITATION {"citationID":"pZ0gQqdG","properties":{"formattedCitation":"\\super [15]\\nosupersub{}","plainCitation":"[15]","noteIndex":0},"citationItems":[{"id":4481,"uris":["http://zotero.org/users/8987489/items/S4EQ55SG"],"itemData":{"id":4481,"type":"article-journal","container-title":"International Journal of Advanced Biochemistry Research","DOI":"10.33545/26174693.2018.v2.i1a.7","ISSN":"26174693, 26174707","issue":"1","journalAbbreviation":"Int. J. Adv. Biochem. Res.","page":"01-05","source":"DOI.org (Crossref)","title":"Review of epidemiology, diagnosis, control, therapeutics and vaccine development for Crimean-Congo hemorrhagic fever","volume":"2","author":[{"family":"Siddiqui","given":"Faizan Q"},{"family":"Parveen","given":"Ghazala"},{"family":"Hussain","given":"Shahzad"}],"issued":{"date-parts":[["2018",1,1]]}}}],"schema":"https://github.com/citation-style-language/schema/raw/master/csl-citation.json"} [15].This synthesis underscores the dual imperative of addressing Afghanistan’s immediate diagnostic gaps while building long-term resilience through One Health approaches that bridge human, animal, and vector surveillance.Limitations of Current ResearchWhile significant advances have been made in understanding CCHFV at the molecular level, several limitations remain. The heterogeneity of CCHFV strains and the complexity of its genomic structure present challenges in the development of universal diagnostic assays and vaccines. Moreover, many of the innovative molecular techniques reviewed here are still in the experimental or early clinical trial phases, and their scalability in resource-limited settings like Afghanistan is yet to be demonstrated.Future studies should focus on longitudinal surveillance to monitor the evolution of CCHFV in endemic areas, especially in Afghanistan, where the virus appears to be emerging rapidly. Integrating molecular data with epidemiological and clinical outcomes will be critical for evaluating the real-world impact of these technological advances. Conclusion The integration of modern molecular biology advances into the diagnosis and management of Crimean–Congo hemorrhagic fever holds significant promise, particularly in high-risk regions such as Afghanistan. Enhanced molecular diagnostics, such as RT-PCR, antigen capture ELISAs, and innovative biosensor technologies, offer the potential for rapid and accurate detection of CCHFV, thereby facilitating early treatment and reducing mortality. Moreover, molecular epidemiological studies have provided critical insights into the genetic diversity and evolution of CCHFV, information that is essential for the development of cross-protective vaccines and targeted therapeutics. However, challenges remain in translating these advances into routine public health practice. In Afghanistan, where laboratory capacity and healthcare infrastructure are often limited, strategic investments in diagnostic technology, personnel training, and international collaborations are urgently needed. Addressing these challenges will not only improve the management of CCHF but will also strengthen the country’s overall preparedness for emerging infectious diseases. This systematic review underscores the importance of continued research into the molecular biology of CCHFV and highlights the potential for these advances to transform the landscape of CCHF diagnosis, treatment, and prevention in Afghanistan. Ultimately, a concerted effort that combines molecular innovations with robust epidemiological surveillance will be key to curbing the impact of this high-fatality disease.Conflict of Interest statementThe authors declare that they have no conflicts of interest. FundingNo funding was received for this study.Authors' ContributionsRahim Bakhsh Faqiryar and Ahmad Saeed Yaqubi wrote the original draft. Rahim Bakhsh Faqiryar and Ahmad Saeed Yaqubi reviewed and edited the manuscript.AcknowledgmentsThe authors are grateful to the Jami University Research Center.ORCIDRahim Bakhsh Faqiryarhttps://orcid.org/0009-0000-3409-594X Ahmad Saeed Yaqubihttps://orcid.org/0009-0008-8757-3050 References ADDIN ZOTERO_BIBL {"uncited":[],"omitted":[],"custom":[]} CSL_BIBLIOGRAPHY 1. Serretiello E, Astorri R, Chianese A, Stelitano D, Zannella C, Folliero V, et al. The emerging tick-borne Crimean-Congo haemorrhagic fever virus: A narrative review. Travel Med Infect Dis 2020;37:101871. https://doi.org/10.1016/j.tmaid.2020.101871. 2. Al-Abri SS, Abaidani IA, Fazlalipour M, Mostafavi E, Leblebicioglu H, Pshenichnaya N, et al. Current status of Crimean-Congo haemorrhagic fever in the World Health Organization Eastern Mediterranean Region: issues, challenges, and future directions. Int J Infect Dis 2017;58:82–9. https://doi.org/10.1016/j.ijid.2017.02.018.3. Jafari A, Asadolahi S, Rasekh M, Saadati D, Faghihi F, Fazlalipour M, et al. Distribution and biodiversity components of hard ticks as potential vectors of Crimean-Congo haemorrhagic fever virus (CCHFV) in borderline of Iran-Afghanistan. Int J Acarol 2021;47(6):510–9. https://doi.org/10.1080/01647954.2021.1954085.4. Kraus AA, Mirazimi A. Molecular Biology and Pathogenesis of Crimean–Congo Hemorrhagic Fever Virus. Future Virol 2010;5(4):469–79. https://doi.org/10.2217/fvl.10.23.5. Shayan S, Bokaean M, Shahrivar MR, Chinikar S. Crimean-Congo Hemorrhagic Fever. Lab Med 2015;46(3):180–9. https://doi.org/10.1309/LMN1P2FRZ7BKZSCO.6. Zeller H. Laboratory Diagnosis of Crimean-Congo Hemorrhagic Fever [Internet]. In: Ergonul O, Whitehouse CA, editors. Crimean-Congo Hemorrhagic Fever. Dordrecht: Springer Netherlands; 2007 [cited 2025 Mar 24]. page 233–43.Available from: http://link.springer.com/10.1007/978-1-4020-6106-6_18. https://doi.org/10.1007/978-1-4020-6106-6_18.7. Freitas N, Legros V, Cosset FL. Crimean-Congo hemorrhagic fever: a growing threat to Europe. C R Biol 2022;345(1):17–36. https://doi.org/10.5802/crbiol.78.8. Munibullah, Yousaf A, Shah M, Habibullah, Sadia H, Sohoo M ur R. Crimean-Congo hemorrhagic fever a threat to public health. 2018;2:1–7. 9. Rahmani K, Behrad R, Rahimi A, Shayan S, Uğurlu G, Shayan NA. Epidemiology and Outcomes of Crimean-Congo Hemorrhagic Fever in Afghanistan: A Review of 2010–2019. Afghan J Infect Dis 2024;2(1):63–74. https://doi.org/10.60141/AJID/V.2.I.1.8.10. Rahimi A, Masudi M, Salehi SA, Binesh MH, Hosaini SF, Shayan NA. Knowledge, attitude, and practices regarding Crimean Congo hemorrhagic fever among students at Jami university, Herat, Afghanistan. Ghalib Med J 1404;2(1):22–9. https://doi.org/10.58342/ghalibMj.V.2.I.1.2.11. Whitehouse C. Crimean?Congo hemorrhagic fever. Antiviral Res 2004;64(3):145–60. https://doi.org/10.1016/j.antiviral.2004.08.001.12. Kalvatchev N, Christova I. Current State of Crimean-Congo Hemorrhagic Fever in Bulgaria. Biotechnol Biotechnol Equip 2012;26(4):3079–85. https://doi.org/10.5504/BBEQ.2011.0135.13. Ergonul O, Whitehouse CA. Crimean-Congo hemorrhagic fever: a global perspective. 2007;14. Flusin O, Iseni F, Rodrigues R, Paranhos-Baccalà G, Crance J, Marianneau P, et al. Crimean-Congo hemorrhagic fever: basics for general practitioners. Med Trop Rev Corps Sante Colon 2010;70 5-6:429–38. 15. Siddiqui FQ, Parveen G, Hussain S. Review of epidemiology, diagnosis, control, therapeutics and vaccine development for Crimean-Congo hemorrhagic fever. Int J Adv Biochem Res 2018;2(1):01–5. https://doi.org/10.33545/26174693.2018.v2.i1a.7. 16. Peyrefitte C, Marianneau P, Tordo N, Bouloy M. Crimean-Congo haemorrhagic fever: -EN- -FR- Fièvre hémorragique de Crimée-Congo -ES- Fiebre hemorrágica de Crimea-Congo. Rev Sci Tech OIE 2015;34(2):390–401. https://doi.org/10.20506/rst.34.2.2365.17. D’Addiego J, Shah S, Pektaş AN, Bağci BK, Öz M, Sebastianelli S, et al. Development of targeted whole genome sequencing approaches for Crimean-Congo haemorrhagic fever virus (CCHFV). Virus Res 2024;350:199464. https://doi.org/10.1016/j.virusres.2024.199464.18. Huang H, Hua X, Pang X, Zhang Z, Ren J, Cheng J, et al. Discovery and Characterization of Putative Glycoprotein-Encoding Mycoviruses in the Bunyavirales. J Virol 2023;97(1):e01381-22. https://doi.org/10.1128/jvi.01381-22.19. Muzammil K, Rayyani S, Abbas Sahib A, Gholizadeh O, Naji Sameer H, Jwad Kazem T, et al. Recent Advances in Crimean-Congo Hemorrhagic Fever Virus Detection, Treatment, and Vaccination: Overview of Current Status and Challenges. Biol Proced Online 2024;26(1):20. https://doi.org/10.1186/s12575-024-00244-3.20. Hewson R, Chamberlain J, Mioulet V, Lloyd G, Jamil B, Hasan R, et al. Crimean-Congo haemorrhagic fever virus: sequence analysis of the small RNA segments from a collection of viruses world wide. Virus Res 2004;102(2):185–9. https://doi.org/10.1016/j.virusres.2003.12.035.21. Fernández De Mera IG, Chaligiannis I, Hernández-Jarguín A, Villar M, Mateos-Hernández L, Papa A, et al. Combination of RT-PCR and proteomics for the identification of Crimean-Congo hemorrhagic fever virus in ticks. Heliyon 2017;3(7):e00353. https://doi.org/10.1016/j.heliyon.2017.e00353.22. Morikawa S, Saijo M, Kurane I. Recent progress in molecular biology of Crimean–Congo hemorrhagic fever. Comp Immunol Microbiol Infect Dis 2007;30(5):375–89. https://doi.org/10.1016/j.cimid.2007.07.001.23. Umair M, Haider SA, Ali Q, Hakim R, Raisani MA, Ayub A, et al. WITHDRAWN: Genomic characterization of Crimean-Congo Hemorrhagic Fever Virus detected during nosocomial outbreak (2023) in Balochistan province of Pakistan [Internet]. 2023 [cited 2025 Mar 24];Available from: http://medrxiv.org/lookup/doi/10.1101/2023.11.28.23299125. https://doi.org/10.1101/2023.11.28.23299125.24. Shrivastava N, Kumar JS, Yadav P, Shete AM, Jain R, Shrivastava A, et al. Development of double antibody sandwich ELISA as potential diagnostic tool for rapid detection of Crimean-Congo hemorrhagic fever virus. Sci Rep 2021;11(1):14699. https://doi.org/10.1038/s41598-021-93319-0.25. Sahak MN, Arifi F, Saeedzai SA. Descriptive epidemiology of Crimean-Congo Hemorrhagic Fever (CCHF) in Afghanistan: Reported cases to National Surveillance System, 2016–2018. Int J Infect Dis 2019;88:135–40. https://doi.org/10.1016/j.ijid.2019.08.016.26. Umair M, Haider SA, Ali Q, Hakim R, Raisani MA, Ayub A, et al. Genomic characterization of Crimean-Congo Hemorrhagic Fever Virus detected during nosocomial outbreak (2023) in Balochistan province of Pakistan [Internet]. 2023 [cited 2025 Mar 24];2023.11.28.23299125. Available from: https://www.medrxiv.org/content/10.1101/2023.11.28.23299125v1. https://doi.org/10.1101/2023.11.28.23299125.27. Oliveira Roster KI, Kissler SM, Omoregie E, Wang JC, Amin H, Di Lonardo S, et al. Surveillance strategies for the detection of new pathogen variants across epidemiological contexts. PLOS Comput Biol 2024;20(9):e1012416. https://doi.org/10.1371/journal.pcbi.1012416.28. Ijaz M, Rahim A, Ali I. Crimean-Congo Hemorrhagic Fever Virus in Pakistan. Infect Disord - Drug Targets [Internet] 2017 [cited 2025 Mar 24];17(2). Available from: http://www.eurekaselect.com/149352/article. https://doi.org/10.2174/1871526517666170117125733.29. Tripp RA, Stambas J. Intervention Strategies for Seasonal and Emerging Respiratory Viruses with Drugs and Vaccines Targeting Viral Surface Glycoproteins. Viruses 2021;13(4):625. https://doi.org/10.3390/v13040625.30. Panthi S, Hong JY, Satange R, Yu CC, Li LY, Hou MH. Antiviral drug development by targeting RNA binding site, oligomerization and nuclear export of influenza nucleoprotein. Int J Biol Macromol 2024;282:136996. https://doi.org/10.1016/j.ijbiomac.2024.136996.31. Niazi A ur R, Jawad MJ, Amirnajad A, Durr PA, Williams DT. Crimean-Congo Hemorrhagic Fever, Herat Province, Afghanistan, 2017 - Volume 25, Number 8—August 2019 - Emerging Infectious Diseases journal - CDC. [cited 2025 Apr 15];Available from: https://wwwnc.cdc.gov/eid/article/25/8/18-1491_article. https://doi.org/10.3201/eid2508.181491.32. Epizootiology and seroprevalence of Crimean-Congo hemorrhagic fever virus in ruminant population of East Afghanistan. Kuwait J Sci 2024;51(1):100131. https://doi.org/10.1016/j.kjs.2023.09.005.33. Mazzola LT, Kelly-Cirino C. Diagnostic tests for Crimean-Congo haemorrhagic fever: a widespread tickborne disease. BMJ Glob Health 2019;4(Suppl 2):e001114. https://doi.org/10.1136/bmjgh-2018-001114.34. Zivcec M, Scholte F, Spiropoulou C, Spengler J, Bergeron É. Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus. Viruses 2016;8(4):106. https://doi.org/10.3390/v8040106.35. Shahhosseini N, Wong G, Babuadze G, Camp JV, Ergonul O, Kobinger GP, et al. Crimean-Congo Hemorrhagic Fever Virus in Asia, Africa and Europe. Microorganisms 2021;9(9):1907. https://doi.org/10.3390/microorganisms9091907.36. Umair M, Rehman Z, Whitmer S, Mobley M, Fahim A, Ikram A, et al. Crimean-Congo Hemorrhagic Fever Virus Diversity and Reassortment, Pakistan, 2017–2020 - Volume 30, Number 4—April 2024 - Emerging Infectious Diseases journal - CDC. [cited 2025 Apr 15];Available from: https://wwwnc.cdc.gov/eid/article/30/4/23-1155_article. https://doi.org/10.3201/eid3004.231155.37. Soozangar N, Jeddi F, Spotin A, Molaei S, Mohammadi-Ghalehbin B, Habibzadeh S, et al. Molecular characterization and phylogenetic analysis of Crimean-Congo hemorrhagic fever virus, northwestern of Iran. BMC Infect Dis 2025;25(1):1–7. https://doi.org/10.1186/s12879-025-10728-6.38. Papa A, Mirazimi A, Köksal I, Estrada-Pena A, Feldmann H. Recent advances in research on Crimean-Congo hemorrhagic fever. J Clin Virol 2015;64:137–43. https://doi.org/10.1016/j.jcv.2014.08.029.39. Shahhosseini N, Wong G, Babuadze G, Camp JV, Ergonul O, Kobinger GP, et al. Crimean-Congo Hemorrhagic Fever Virus in Asia, Africa and Europe. Microorganisms 2021;9(9):1907. https://doi.org/10.3390/microorganisms9091907.40. Karanam SK, Nagvishnu K, Uppala PK, Edhi S, Varri SR. Crimean-Congo hemorrhagic fever: Pathogenesis, transmission and public health challenges. World J Virol [Internet] 2025 [cited 2025 Mar 25];14(1). Available from: https://www.wjgnet.com/2220-3249/full/v14/i1/100003.htm. https://doi.org/10.5501/wjv.v14.i1.100003.41. Public Health Agency of Canada. Crimean-Congo hemorrhagic fever virus: Infectious substances pathogen safety data sheet [Internet]. 2001 [cited 2025 Apr 15];Available from: https://www.canada.ca/en/public-health/services/laboratory-biosafety-biosecurity/pathogen-safety-data-sheets-risk-assessment/crimean-congo-haemorrhagic-fever-virus.html-5714-45085Ghalib International Journal of Medical Sciences, (Ghalib.Med.J). Autumn and winter. 2(2). pp. 65-7400Ghalib International Journal of Medical Sciences, (Ghalib.Med.J). Autumn and winter. 2(2). pp. 65-741569720777875 About Afghanistan Journal of Infectious Diseases00 About Afghanistan Journal of Infectious Diseases387191-2222Ghalib International Journal of Medical Sciences, (Ghalib.Med.J). Autumn and winter. 2(2). pp. 65-7400Ghalib International Journal of Medical Sciences, (Ghalib.Med.J). Autumn and winter. 2(2). pp. 65-74-104445-42545Ahmad Saeed Yaqubi et al.00Ahmad Saeed Yaqubi et al. PAGE \* MERGEFORMAT 74 951547-54610KAP Regarding CCHF Among Students at Jami University, Herat, Afghanistan00KAP Regarding CCHF Among Students at Jami University, Herat, Afghanistan PAGE \* Arabic \* MERGEFORMAT 73iVBORw0KGgoAAAANSUhEUgAAAFgAAAAfCAMAAABUFvrSAAAAIGNIUk0AAHolAACAgwAA+f8AAIDp
AAB1MAAA6mAAADqYAAAXb5JfxUYAAAAEZ0FNQQAAsY58+1GTAAAAAXNSR0IB2cksfwAAAW5QTFRF
////////////////7+/v39/f1tXV09bS0tXS0tXR0dTR0dTQ0NTQ0NPPz9PPztLOztHNzdHNzdHM
z8/PzdDMzNDMzNDLzM/Ly8/Ly8/Ky87Kys3Jyc3Jyc3IyMzIyMzHx8vHxsrGxsrFxcnFxcnExMnE
xMjDw8jDxMfDw8fCwsfCwcXAwMXAwMW/wMS/v8S+v8O+vsO+vsK9vcK9vcK8v7+/vMG8vMG7vMC8
u8C7u8C6ur+6ur+5ub65ub64uL23t7y2tru1tbq0tLqztLmzs7iysrixsrexsbewsbawsLavsLWv
r7Wur7SusLOvrrStrrOtr7KvrbOsrLKrr6+vq7Gqn6OenqCdn5+flpmWk5iTkZSRkZORj4+PiYyJ
hIaEhIWEgoWCgICAfX98fH98eXx5cHJvcHBwYGBgXV5dUFFQUFBQQ0RDQEBAPj8+NTY1MjMxMDAw
KSkpKCkoICAgGxsbEBAQDg4ODQ4NAAAAlzoSDQAAAAN0Uk5TAAoO5yEBUwAAAvhJREFUeNq1lutX
2kAQxWmXFDVGYy1EIjQ2VZDiu1CsRQQURYvV+qSKj6II8rANYOT+9z0JqIASo9Y5ydkP2f2d2Ts7
d2N4jRcJgwEIBwO+SbdTFGw8ZzZz1n5BdLgnfLPBcCT6fW1jY3P78QEYEA76PWMu0W5lGbrNZGrr
YNg+u+ga9fgVcmxtY/NJZAOCfs+IY4Bn6eN8RdlEJX9Ed1uFIfdnfzC8uBJbv5tyqqhMLKa0wQHP
iEOwMInLW4Eu9xmzfdDtmQ0uLK3cSXmvBBTS6QJQ2tMC+8YcgpnOApAzSa83mZEBZIff2odGfYFQ
JNqc8s4VchQhhFA5XO1pgCddAxaFKyeNpBpxGSgNmwXXxMxcWE25fkkJGUIIoExESQPsFnkmC0gU
uQmjBGQZq+j2BEKR5dUGLVLIvbkGkxxSrcHO92wCkIyENJL3u+2O8Zng/FJsvR5cRF0GFIqtwaKV
voTcSxrCKOOS7hPdXwLhxUYtUFC+Z6AKQgpoDRZ6joEkaYo4cMQKril/KLLcCE4TVYmqFmkNsK0r
D9lIiDdXKCSrwwEhREae6Ve0WIiuPg3M0xVlW171BBe21CGjbLbSYR0c/To3H409TQquHTggREKZ
8pbjEiRqqxxXtWjjRLdvLrzUAK4Vr5qwZvEsJsCrzExWF9Tk9gIm84e74BRyRN9xeyS4vkHSmg1y
K4Wxt5yUIClDayn0t3SteLWq3RQvjQrN31O87e2dEiBl0tJDJmTrykImN8dtq6AOpIw8Y3OMf2s+
bvptU+hJqFrc1yCfpmZDkWYX0mv0H9WWpvS2tH6w8z27e58JJVi7c2ImuNBkQvrBOOWZc0CqsyFK
tU3+97OuaQBnXGe90RuTMvCHtpziuWCcmDvPm64m+t2vlmuq/YHqqwnGCcfs1l+mCcbSmgtSe8iD
GQNnPEsnrq//fZrltXS4tk3oAOPvT2tPF91uMrXTDNv340JrjQ4hbsHAxeE0z1ksHD99eKFdl0dl
/P//Cl+9EPcfS+yBAoqk3eUAAAAASUVORK5CYII=/9j/4AAQSkZJRgABAQEA3ADcAAD/2wBDAAIBAQEBAQIBAQECAgICAgQDAgICAgUEBAMEBgUGBgYF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=iVBORw0KGgoAAAANSUhEUgAAACkAAAAnCAIAAAAdCPbRAAAAAXNSR0IArs4c6QAAAARnQU1BAACx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iVBORw0KGgoAAAANSUhEUgAAAPgAAAD4CAYAAADB0SsLAAAAAXNSR0IArs4c6QAAAARnQU1BAACx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iVBORw0KGgoAAAANSUhEUgAAACEAAAAfCAIAAADm9jPlAAAAAXNSR0IArs4c6QAAAARnQU1BAACx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iVBORw0KGgoAAAANSUhEUgAAAOEAAAEPCAYAAAC0iqM8AAAAAXNSR0IArs4c6QAAAARnQU1BAACx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=<data data-version="3" zotero-version="7.0.24"><session id="ptf7L35F"/><style id="http://www.zotero.org/styles/vancouver-superscript-brackets-only-year" locale="en-US" hasBibliography="1" bibliographyStyleHasBeenSet="1"/><prefs><pref name="fieldType" value="Field"/><pref name="automaticJournalAbbreviations" value="true"/><pref name="dontAskDelayCitationUpdates" value="true"/></prefs></data>RahmaniGhulamRasoulRahmani22025-09-15T15:10:00Z2025-09-15T15:11:00Z2025-09-15T15:11:00ZNormal01017965102402Microsoft Office Word0853240falseTitle1Título1false120127falsefalse14.0000